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- W1550873973 abstract "Abstract The chemotherapeutic agent cisplatin enjoys the status of one of the world's best‐selling anticancer drugs. As is the case with other chemotherapeutic drugs, however, cisplatin has its drawbacks, including intrinsic or acquired resistance and toxicity. Efforts to mitigate cisplatin's drawbacks have inspired the synthesis of myriad analogs, but with only a handful that have been shown to be acceptable for clinical application. Increased understanding of the mechanism of the action of cisplatin, as a result of decades of research, is leading to a more rational design of new platinum drugs. However, the incomplete puzzle of cisplatin's ways and the lack of a single decisive biological target for anticancer treatment still complicate the search for improved platinum drugs. This article gives a brief introduction to cisplatin, and subsequently summarizes and evaluates the development of cisplatin derivatives and possible new approaches." @default.
- W1550873973 created "2016-06-24" @default.
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- W1550873973 date "2005-09-07" @default.
- W1550873973 modified "2023-09-23" @default.
- W1550873973 title "Platinum-Based Anticancer DrugsBased in part on the article Platinum-Based Anticancer Drugs by Steven J. Brown, Christine S. Chow & Stephen J. Lippard which appeared in theEncyclopedia of Inorganic Chemistry, First Edition." @default.
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- W1550873973 doi "https://doi.org/10.1002/0470862106.ia193" @default.
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