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- W1550958056 abstract "Publisher Summary This chapter focuses on comparative genomics, cis-regulatory elements, and gene duplication. It discusses the component of the genome that is much less tangible than the coding sequences, but might be equally important in its physiological and ontogenetic functioning: the noncoding cis-regulatory component. For the information embedded in a genome to be fully realized, the sequence needs to be compared with those of other taxa, that is, by procuring sequences from orthologous regions of different genomes for comparison and scrutiny. Because of the extensive sequence divergences in the noncoding components of genomes, it is often very difficult to align such regions by using conventional local alignment tools such as BLASTN. Based on genetic maps as well as analyses of whole-genome sequences, there is strong evidence that euteleosts (e.g., medaka, pufferfish, and zebrafish) have undergone an independent genome duplication roughly 300 million years ago. Because many of these gene duplicates have been retained in zebrafish, the genome sequence provides a very good opportunity to study the molecular evolution and fates of duplicated genes following a large-scale duplication event. The chapter also describes computational tools for delineating conserved cis elements when comparing syntenic regions of different genomic sequences. Some of these methods result in relatively crude visualization of the conserved regions and can serve as first pass methods for examining the data." @default.
- W1550958056 created "2016-06-24" @default.
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- W1550958056 date "2004-01-01" @default.
- W1550958056 modified "2023-09-27" @default.
- W1550958056 title "Comparative Genomics, cis-Regulatory Elements, and Gene Duplication" @default.
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- W1550958056 doi "https://doi.org/10.1016/s0091-679x(04)77029-6" @default.
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- W1550958056 hasPublicationYear "2004" @default.
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