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- W1550960912 abstract "A total of 105 cases of endometrial carcinoma are studied with regard to (1) age at the onset of the menopause; (2) preceding periods of metrorrhagia; (3) presence or absence of menopausal complaints; (4) marital status and fertility; (5) histological picture of the possibly apparently normal part of the endometrium; (6) intensity and duration of estrogen therapy possibly given. The present studies show that in these cancer patients the menopause commences later and is more often preceded by periodic metrorrhagia, and less frequently accompanied by hot flushes, indicating that these patients have often been under the influence of endogenous estrogens through longer periods than the average woman. The women in this series suffering from cancer of the corpus uteri have often given a history of treatment with estrogens in a larger amount and for a longer duration than was recorded for the controls. Thus 16 of the cancer patients had had continuous treatment with estrogens for from 2 to 15 years (average 6.5 years, Table III). The difficulty in making the histological diagnosis in such cases is pointed out; and it is emphasized that in dubious cases it is essential to keep the patient under observation for a few months without administration of any estrogen before a conclusive biopsy can be performed. During this interval, in some instances a cancerlike hyperplasia of the endometrium will disappear. The conclusion is drawn that a continuous estrogenic stimulation (endogenous or exogenous) constitutes an important factor in the etiology of endometrial cancer. Precautions concerning estrogen therapy in the menopause are emphasized." @default.
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- W1550960912 date "1954-05-01" @default.
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- W1550960912 title "Clinical studies concerning the relationship of estrogens to the development of cancer of the corpus uteri" @default.
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- W1550960912 doi "https://doi.org/10.1016/0002-9378(54)90269-0" @default.
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