Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551030083> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1551030083 endingPage "803" @default.
- W1551030083 startingPage "796" @default.
- W1551030083 abstract "Doxorubicin possesses high affinity for binding to cardiolipin. We have utilized these properties in preparing stable liposomes of doxorubicin and cardiolipin with a net positive charge. Doxorubicin liposomes were formed by using 11.2 mumol of drug, 5.6 mumol of cardiolipin, 28.5 mumol of phosphatidylcholine, 19.5 mumol of cholesterol, and 11.1 mumol of stearylamine. These liposomes were sonicated for 90 min at 37 degrees followed by extensive dialysis against buffer. The pharmacological, toxicological, and therapeutic effects of doxorubicin entrapped in cardiolipin liposomes were compared with those of free doxorubicin in mice. At a dose of 4 mg/kg i.v., the peak cardiac concentration was achieved in 30 min following free doxorubicin administration, the value being 8.1 micrograms/g. The peak cardiac concentration with doxorubicin in cardiolipin liposomes was obtained at 5 min with a value of 2.8 micrograms/g of tissue. The cardiac concentration X time values for free doxorubicin for the 24-hr period of observation were 55.1 micrograms X hr/g, whereas it was only 7.8 micrograms X hr/g with the drug entrapped in cardiolipin liposomes. Compared to free drug, the liposomal entrapped doxorubicin significantly reduced the histopathological lesions in cardiac tissue of mice at a dose of 15 mg/kg as determined by electron microscopy. The nadir of peripheral white blood cell counts in mice with free drug, 6 mg/kg, was observed on Day 3 which was 50% of control, whereas with liposomal encapsulated drug it was reduced only 23% on Day 7. Doxorubicin in cardiolipin liposomes demonstrated enhanced chemotherapeutic potential against murine ascitic P388 leukemia with a 144% increased life span compared to 55% increased life span with free drug at a dose of 7.5 mg/kg on Days 1, 3, and 7. We conclude that doxorubicin liposomes developed in these studies possess improved therapeutic action as demonstrated by their ability to reduce the toxicity of the drug substantially." @default.
- W1551030083 created "2016-06-24" @default.
- W1551030083 creator A5046854196 @default.
- W1551030083 creator A5052787538 @default.
- W1551030083 creator A5062682753 @default.
- W1551030083 creator A5074933318 @default.
- W1551030083 date "1985-02-01" @default.
- W1551030083 modified "2023-09-23" @default.
- W1551030083 title "Pharmacological, toxicological, and therapeutic evaluation in mice of doxorubicin entrapped in cardiolipin liposomes." @default.
- W1551030083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3967247" @default.
- W1551030083 hasPublicationYear "1985" @default.
- W1551030083 type Work @default.
- W1551030083 sameAs 1551030083 @default.
- W1551030083 citedByCount "33" @default.
- W1551030083 countsByYear W15510300832013 @default.
- W1551030083 countsByYear W15510300832015 @default.
- W1551030083 countsByYear W15510300832016 @default.
- W1551030083 countsByYear W15510300832017 @default.
- W1551030083 countsByYear W15510300832018 @default.
- W1551030083 crossrefType "journal-article" @default.
- W1551030083 hasAuthorship W1551030083A5046854196 @default.
- W1551030083 hasAuthorship W1551030083A5052787538 @default.
- W1551030083 hasAuthorship W1551030083A5062682753 @default.
- W1551030083 hasAuthorship W1551030083A5074933318 @default.
- W1551030083 hasConcept C126322002 @default.
- W1551030083 hasConcept C13245373 @default.
- W1551030083 hasConcept C185154212 @default.
- W1551030083 hasConcept C185592680 @default.
- W1551030083 hasConcept C2776330855 @default.
- W1551030083 hasConcept C2776694085 @default.
- W1551030083 hasConcept C2778918659 @default.
- W1551030083 hasConcept C2780035454 @default.
- W1551030083 hasConcept C2781302388 @default.
- W1551030083 hasConcept C2781303535 @default.
- W1551030083 hasConcept C41625074 @default.
- W1551030083 hasConcept C55493867 @default.
- W1551030083 hasConcept C71924100 @default.
- W1551030083 hasConcept C98274493 @default.
- W1551030083 hasConceptScore W1551030083C126322002 @default.
- W1551030083 hasConceptScore W1551030083C13245373 @default.
- W1551030083 hasConceptScore W1551030083C185154212 @default.
- W1551030083 hasConceptScore W1551030083C185592680 @default.
- W1551030083 hasConceptScore W1551030083C2776330855 @default.
- W1551030083 hasConceptScore W1551030083C2776694085 @default.
- W1551030083 hasConceptScore W1551030083C2778918659 @default.
- W1551030083 hasConceptScore W1551030083C2780035454 @default.
- W1551030083 hasConceptScore W1551030083C2781302388 @default.
- W1551030083 hasConceptScore W1551030083C2781303535 @default.
- W1551030083 hasConceptScore W1551030083C41625074 @default.
- W1551030083 hasConceptScore W1551030083C55493867 @default.
- W1551030083 hasConceptScore W1551030083C71924100 @default.
- W1551030083 hasConceptScore W1551030083C98274493 @default.
- W1551030083 hasIssue "2" @default.
- W1551030083 hasLocation W15510300831 @default.
- W1551030083 hasOpenAccess W1551030083 @default.
- W1551030083 hasPrimaryLocation W15510300831 @default.
- W1551030083 hasRelatedWork W1551030083 @default.
- W1551030083 hasRelatedWork W1972667911 @default.
- W1551030083 hasRelatedWork W1983399925 @default.
- W1551030083 hasRelatedWork W1988382716 @default.
- W1551030083 hasRelatedWork W2050614342 @default.
- W1551030083 hasRelatedWork W2093442802 @default.
- W1551030083 hasRelatedWork W2109141943 @default.
- W1551030083 hasRelatedWork W2133756116 @default.
- W1551030083 hasRelatedWork W2527196887 @default.
- W1551030083 hasRelatedWork W2891009951 @default.
- W1551030083 hasVolume "45" @default.
- W1551030083 isParatext "false" @default.
- W1551030083 isRetracted "false" @default.
- W1551030083 magId "1551030083" @default.
- W1551030083 workType "article" @default.