Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551118417> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1551118417 endingPage "3637" @default.
- W1551118417 startingPage "3630" @default.
- W1551118417 abstract "Abstract Synthesis of liver ferritin induced by iron administration was investigated by treating rats by injection with pulse doses of leucine-14C at various times after a single intraperitoneal dose of iron. The iron caused a rapid but transient increase of leucine uptake into ferritin without affecting incorporation into mixed liver proteins; the ferritin response was dose-dependent and was followed by an increase in liver ferritin content. Since the action of iron was insensitive to actinomycin D, it was considered to be independent of synthesis of new messenger ribonucleic acid. Ferritin turnover was studied by following loss of radioactivity from liver ferritin over a 72-hour period after leucine-14C administration. Repeated injections of iron during this period increased the iron to protein ratio of ferritin and retarded loss of radioactivity, thus suggesting that iron-rich ferritin molecules are less susceptible than iron-poor molecules to degradation. With the use of a sucrose density gradient to separate ferritin species of differing iron content, it was shown that the first fraction to become labeled after injection of leucine-14C was low in iron. Subsequently there was progressive transfer of the label to ferritin fractions richer in iron over a 72-hour period. Repeated injection of iron caused a larger proportion of the initial radioactivity of the iron-poor fraction to be retained as iron-rich ferritin. To explain the actions of iron on ferritin metabolism by a single unifying hypothesis, it is proposed that iron can cause an apparent induction by stabilizing an unstable precursor of ferritin which would otherwise be rapidly degraded, and that iron can also stabilize iron-poor ferritin molecules by increasing their iron content and thus retarding their degradation." @default.
- W1551118417 created "2016-06-24" @default.
- W1551118417 creator A5033446709 @default.
- W1551118417 creator A5046590022 @default.
- W1551118417 date "1966-08-01" @default.
- W1551118417 modified "2023-10-09" @default.
- W1551118417 title "Regulation of Synthesis and Turnover of Ferritin in Rat Liver" @default.
- W1551118417 cites W129615950 @default.
- W1551118417 cites W1574621696 @default.
- W1551118417 cites W1679641904 @default.
- W1551118417 cites W1775749144 @default.
- W1551118417 cites W1856530031 @default.
- W1551118417 cites W1939956415 @default.
- W1551118417 cites W1974751353 @default.
- W1551118417 cites W2024332926 @default.
- W1551118417 cites W2064359185 @default.
- W1551118417 cites W2075828468 @default.
- W1551118417 cites W2077255312 @default.
- W1551118417 cites W2085449602 @default.
- W1551118417 cites W2131490420 @default.
- W1551118417 cites W2170042106 @default.
- W1551118417 cites W2252590791 @default.
- W1551118417 cites W2292337838 @default.
- W1551118417 cites W2408832556 @default.
- W1551118417 cites W2409681326 @default.
- W1551118417 cites W2414073599 @default.
- W1551118417 cites W2416825366 @default.
- W1551118417 cites W87368744 @default.
- W1551118417 doi "https://doi.org/10.1016/s0021-9258(18)99877-7" @default.
- W1551118417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5919688" @default.
- W1551118417 hasPublicationYear "1966" @default.
- W1551118417 type Work @default.
- W1551118417 sameAs 1551118417 @default.
- W1551118417 citedByCount "296" @default.
- W1551118417 countsByYear W15511184172012 @default.
- W1551118417 countsByYear W15511184172014 @default.
- W1551118417 countsByYear W15511184172015 @default.
- W1551118417 countsByYear W15511184172016 @default.
- W1551118417 countsByYear W15511184172018 @default.
- W1551118417 countsByYear W15511184172019 @default.
- W1551118417 countsByYear W15511184172020 @default.
- W1551118417 countsByYear W15511184172022 @default.
- W1551118417 countsByYear W15511184172023 @default.
- W1551118417 crossrefType "journal-article" @default.
- W1551118417 hasAuthorship W1551118417A5033446709 @default.
- W1551118417 hasAuthorship W1551118417A5046590022 @default.
- W1551118417 hasBestOaLocation W15511184171 @default.
- W1551118417 hasConcept C126322002 @default.
- W1551118417 hasConcept C134018914 @default.
- W1551118417 hasConcept C185592680 @default.
- W1551118417 hasConcept C2778319317 @default.
- W1551118417 hasConcept C2908801736 @default.
- W1551118417 hasConcept C55493867 @default.
- W1551118417 hasConcept C71924100 @default.
- W1551118417 hasConcept C86803240 @default.
- W1551118417 hasConceptScore W1551118417C126322002 @default.
- W1551118417 hasConceptScore W1551118417C134018914 @default.
- W1551118417 hasConceptScore W1551118417C185592680 @default.
- W1551118417 hasConceptScore W1551118417C2778319317 @default.
- W1551118417 hasConceptScore W1551118417C2908801736 @default.
- W1551118417 hasConceptScore W1551118417C55493867 @default.
- W1551118417 hasConceptScore W1551118417C71924100 @default.
- W1551118417 hasConceptScore W1551118417C86803240 @default.
- W1551118417 hasIssue "15" @default.
- W1551118417 hasLocation W15511184171 @default.
- W1551118417 hasOpenAccess W1551118417 @default.
- W1551118417 hasPrimaryLocation W15511184171 @default.
- W1551118417 hasRelatedWork W1966504330 @default.
- W1551118417 hasRelatedWork W1966775726 @default.
- W1551118417 hasRelatedWork W1979139803 @default.
- W1551118417 hasRelatedWork W1991560548 @default.
- W1551118417 hasRelatedWork W2030889776 @default.
- W1551118417 hasRelatedWork W2037631372 @default.
- W1551118417 hasRelatedWork W2040058909 @default.
- W1551118417 hasRelatedWork W2132898409 @default.
- W1551118417 hasRelatedWork W2748952813 @default.
- W1551118417 hasRelatedWork W4249176446 @default.
- W1551118417 hasVolume "241" @default.
- W1551118417 isParatext "false" @default.
- W1551118417 isRetracted "false" @default.
- W1551118417 magId "1551118417" @default.
- W1551118417 workType "article" @default.