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- W1551135499 abstract "This chapter discusses the effect of neonatal thymectomy in suppressing subsequent immunologic responsiveness and the extent to that immunologically competent cell originate in the thymus. It has often been debated whether the thymus plays a significant part in immunological reactions. On the one hand, there are hints from clinical observations that the thymus may play some role. For instance, in acute infections, when presumably the need for an immunological response with antibody production is great, the thymus undergoes rapid involution. On the other hand, there are experimental studies that show that the intact thymus does not produce antibody in immunized animals. Immunological reactivity of the thymus, such as antibody production in the thymus and immunological competence of thymus cells, is discussed in the chapter. Studies of the response to standard antigens of animals thymectomized as adults have revealed either slight or no impairment of antibody production. Immunological status of thymectomized animals, such as longevity, humoral immunity, homograft immunity, delayed hypersensitivity, cell transfer studies, and immune status following thymus grafting, is discussed in the chapter. As the thymus is the major lymphoid organ in perinatal life, at a time when the response to antigen can easily be modified, it is possible that thymectomy at an early age might be associated with some detectable effect on immunological response. Systemic disorders associated with primary thymic disease in man, such as pathology of the thymus gland associated with systemic disorder, association of thymic hyperplasia with disorders of serum proteins and blood formation, pathology of thymic tumors associated with systemic disorders, and the pathogenesis of the thymic syndromes in man, are also discussed in the chapter." @default.
- W1551135499 created "2016-06-24" @default.
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- W1551135499 date "1963-01-01" @default.
- W1551135499 modified "2023-09-27" @default.
- W1551135499 title "The Immunological Significance of the Thymus" @default.
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