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- W1551137953 abstract "Publisher Summary This chapter describes drug distribution and “deep pool effect.” Distribution half-life and volume of distribution can be determined for a given drug using conventional or stable isotope labeled (SIL) tracer techniques. Serial injections of SIL drug with different labels are administered at predetermined times prior to collection of a single tissue specimen, such as cerebrospinal fluid, liver, or kidney. The tissue concentration of each SIL form of the drug is determined. The requirement for only a single tissue specimen greatly reduces subject morbidity in comparison with the conventional multiple-specimen technique. If a portion of administered drug is distributed into a “deep” peripheral compartment, the drug's actual elimination half-life during the terminal exponential phase of elimination may be longer than determined by a single dose study, or a tracer dose study if the study is not carried out for a sufficient length of time to detect low plasma concentrations of drug at later times after administration. This is referred as the “deep pool effect” and can lead to an overestimation of actual clearance in single dose studies and in tracer dose studies because of factitiously small values for apparent elimination half-life and apparent area under the plasma concentration versus time curve." @default.
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- W1551137953 date "1997-01-01" @default.
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- W1551137953 title "Chapter 14 Drug distribution and “Deep pool effect”" @default.
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- W1551137953 doi "https://doi.org/10.1016/s0165-7208(97)80161-4" @default.
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