FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551140393> ?p ?o ?g. }

• W1551140393 abstract "Previously, studies showed that subretinal electrical stimulation (SES) from a microphotodiode array (MPA) preserves electroretinography (ERG) b-wave amplitude and regional retinal structure in the Royal College of Surgeons (RCS) rat and simultaneously upregulates Fgf2 expression. This preservation appears to be associated with the increased current produced when the MPA is exposed to ERG test flashes, as weekly ERG testing produces greater neuroprotection than biweekly or no testing. Using an infrared source to stimulate the MPA while avoiding potential confounding effects from exposing the RCS retina to high luminance white light, this study examined whether neuroprotective effects from SES increased with subretinal current in a dose-dependent manner.RCS rats (n=49) underwent subretinal implantation surgery at P21 with MPA devices in one randomly selected eye, and the other eye served as the control. Naïve RCS rats (n=25) were also studied. To increase SES current levels, implanted eyes were exposed to 15 min per session of flashing infrared light (IR) of defined intensity, frequency, and duty cycle. Rats were divided into four SES groups that received ERG testing only (MPA only), about 450 µA/cm2 once per week (Low 1X), about 450 µA/cm2 three times per week (Low 3X), and about 1350 µA/cm2 once per week (High 1X). One eye of the control animals was randomly chosen for IR exposure. All animals were followed for 4 weeks with weekly binocular ERGs. A subset of the eyes was used to measure retina Fgf2 expression with real-time reverse-transcription PCR.Eyes receiving SES showed significant preservation of b-wave amplitude, a- and b-wave implicit times, oscillatory potential amplitudes, and post-receptoral parameters (Vmax and log σ) compared to untreated eyes. All SES-treated eyes had similar preservation, regardless of increased SES from IR light exposure. SES-treated eyes tended to have greater retinal Fgf2 expression than untreated eyes, but Fgf2 expression did not increase with IR light.The larger post-receptoral responses (Vmax), greater post-receptoral sensitivity (logσ), and larger oscillatory potentials suggest SES-treated eyes maintained better inner retinal function than the opposite, untreated eyes. This suggests that in addition to preserving photoreceptors in RCS rats, SES may also promote more robust signal transmission through the retinal network compared to the control eyes. These studies suggest that the protective effects of SES on RCS retinal function cannot be improved with additional subretinal current induction from the MPA, or the charge injection provided by ERG Ganzfeld flashes was not adequately mimicked by the flashing IR light used in this study." @default.
• W1551140393 created "2016-06-24" @default.
• W1551140393 creator A5012234271 @default.
• W1551140393 creator A5033898072 @default.
• W1551140393 creator A5065909406 @default.
• W1551140393 creator A5088860609 @default.
• W1551140393 date "2013-01-01" @default.
• W1551140393 modified "2023-09-26" @default.
• W1551140393 title "Subretinal electrical stimulation preserves inner retinal function in RCS rat retina." @default.
• W1551140393 cites W1150846290 @default.
• W1551140393 cites W1494776563 @default.
• W1551140393 cites W1957804270 @default.
• W1551140393 cites W1969759800 @default.
• W1551140393 cites W1972341463 @default.
• W1551140393 cites W1973520192 @default.
• W1551140393 cites W1975436727 @default.
• W1551140393 cites W1980691020 @default.
• W1551140393 cites W1997772006 @default.
• W1551140393 cites W2001059359 @default.
• W1551140393 cites W2008025759 @default.
• W1551140393 cites W2017515548 @default.
• W1551140393 cites W2018660789 @default.
• W1551140393 cites W2020775580 @default.
• W1551140393 cites W2023033803 @default.
• W1551140393 cites W2028760371 @default.
• W1551140393 cites W2032610026 @default.
• W1551140393 cites W2035825974 @default.
• W1551140393 cites W2040216583 @default.
• W1551140393 cites W2044024607 @default.
• W1551140393 cites W2050613723 @default.
• W1551140393 cites W2051341164 @default.
• W1551140393 cites W2053780851 @default.
• W1551140393 cites W2060597168 @default.
• W1551140393 cites W2061305590 @default.
• W1551140393 cites W2063134208 @default.
• W1551140393 cites W2066983920 @default.
• W1551140393 cites W2094307378 @default.
• W1551140393 cites W2095891880 @default.
• W1551140393 cites W2111817251 @default.
• W1551140393 cites W2113879673 @default.
• W1551140393 cites W2114765964 @default.
• W1551140393 cites W2123805988 @default.
• W1551140393 cites W2146199250 @default.
• W1551140393 cites W2163297261 @default.
• W1551140393 cites W2165178639 @default.
• W1551140393 cites W2170980020 @default.
• W1551140393 cites W2227187219 @default.
• W1551140393 cites W2308764466 @default.
• W1551140393 cites W919388225 @default.
• W1551140393 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3654858" @default.
• W1551140393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23687436" @default.
• W1551140393 hasPublicationYear "2013" @default.
• W1551140393 type Work @default.
• W1551140393 sameAs 1551140393 @default.
• W1551140393 citedByCount "12" @default.
• W1551140393 countsByYear W15511403932014 @default.
• W1551140393 countsByYear W15511403932015 @default.
• W1551140393 countsByYear W15511403932016 @default.
• W1551140393 countsByYear W15511403932018 @default.
• W1551140393 countsByYear W15511403932019 @default.
• W1551140393 countsByYear W15511403932021 @default.
• W1551140393 countsByYear W15511403932022 @default.
• W1551140393 countsByYear W15511403932023 @default.
• W1551140393 crossrefType "journal-article" @default.
• W1551140393 hasAuthorship W1551140393A5012234271 @default.
• W1551140393 hasAuthorship W1551140393A5033898072 @default.
• W1551140393 hasAuthorship W1551140393A5065909406 @default.
• W1551140393 hasAuthorship W1551140393A5088860609 @default.
• W1551140393 hasConcept C103796816 @default.
• W1551140393 hasConcept C118487528 @default.
• W1551140393 hasConcept C169760540 @default.
• W1551140393 hasConcept C24998067 @default.
• W1551140393 hasConcept C25498285 @default.
• W1551140393 hasConcept C2777093970 @default.
• W1551140393 hasConcept C2779113765 @default.
• W1551140393 hasConcept C2780827179 @default.
• W1551140393 hasConcept C71924100 @default.
• W1551140393 hasConcept C86803240 @default.
• W1551140393 hasConceptScore W1551140393C103796816 @default.
• W1551140393 hasConceptScore W1551140393C118487528 @default.
• W1551140393 hasConceptScore W1551140393C169760540 @default.
• W1551140393 hasConceptScore W1551140393C24998067 @default.
• W1551140393 hasConceptScore W1551140393C25498285 @default.
• W1551140393 hasConceptScore W1551140393C2777093970 @default.
• W1551140393 hasConceptScore W1551140393C2779113765 @default.
• W1551140393 hasConceptScore W1551140393C2780827179 @default.
• W1551140393 hasConceptScore W1551140393C71924100 @default.
• W1551140393 hasConceptScore W1551140393C86803240 @default.
• W1551140393 hasLocation W15511403931 @default.
• W1551140393 hasOpenAccess W1551140393 @default.
• W1551140393 hasPrimaryLocation W15511403931 @default.
• W1551140393 hasRelatedWork W1129596533 @default.
• W1551140393 hasRelatedWork W158563593 @default.
• W1551140393 hasRelatedWork W1969759800 @default.
• W1551140393 hasRelatedWork W1973520192 @default.
• W1551140393 hasRelatedWork W1978820247 @default.
• W1551140393 hasRelatedWork W2017515548 @default.
• W1551140393 hasRelatedWork W2066983920 @default.
• W1551140393 hasRelatedWork W2073512453 @default.
• W1551140393 hasRelatedWork W2074715006 @default.

• next