Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551148764> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1551148764 endingPage "4852" @default.
- W1551148764 startingPage "4845" @default.
- W1551148764 abstract "// Alexis Saintamand 1 , Pauline Rouaud 1 , Armand Garot 1 , Faten Saad 1 , Claire Carrion 1 , Christelle Oblet 1 , Michel Cogné 1, 2, 3 , Eric Pinaud 1 , Yves Denizot 1 1 CNRS, CRIBL, UMR 7276, Limoges, France 2 Université de Limoges, CRIBL, UMR 7276, Limoges, France 3 Institut Universitaire de France, Paris, France Correspondence to: Yves Denizot, e-mail: yves.denizot@unilim.fr Keywords: BCR, B cell fate, IgH 3’ regulatory enhancers, knock-out mice Received: December 17, 2014 Accepted: December 21, 2014 Published: March 03, 2015 ABSTRACT We report that the IgH 3’ regulatory region (3’RR) has no role on μ chain transcription and pre-BCR expression in B cell progenitors. In contrast, analysis of heterozygous IgH a Δ3’RR /b wt mice indicated that the 3’RR controls μ chain transcripts in mature splenocytes and impacts membrane IgM density without obvious effect on BCR signals (colocalisation with lipid rafts and phosphorylation of Erk and Akt after BCR crosslinking). Deletion of the 3’RR modulates the B cell fate to less marginal zone B cells. In conclusion, the 3’RR is dispensable for pre-BCR expression and necessary for optimal commitments toward the marginal zone B cell fate. These results reinforce the concept of a dual regulation of the IgH locus transcription and accessibility by 5’ elements at immature B cell stages, and by the 3’RR as early as the resting mature B cell stage and then along further activation and differentiation." @default.
- W1551148764 created "2016-06-24" @default.
- W1551148764 creator A5035009833 @default.
- W1551148764 creator A5037574721 @default.
- W1551148764 creator A5043525645 @default.
- W1551148764 creator A5048010568 @default.
- W1551148764 creator A5051446250 @default.
- W1551148764 creator A5061875124 @default.
- W1551148764 creator A5063574799 @default.
- W1551148764 creator A5074219370 @default.
- W1551148764 creator A5085662031 @default.
- W1551148764 date "2015-03-03" @default.
- W1551148764 modified "2023-10-15" @default.
- W1551148764 title "The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate" @default.
- W1551148764 cites W1562378545 @default.
- W1551148764 cites W1589053023 @default.
- W1551148764 cites W1805312813 @default.
- W1551148764 cites W1813376539 @default.
- W1551148764 cites W182737502 @default.
- W1551148764 cites W1930093851 @default.
- W1551148764 cites W1972307026 @default.
- W1551148764 cites W1980546626 @default.
- W1551148764 cites W2005862926 @default.
- W1551148764 cites W2017265557 @default.
- W1551148764 cites W2018386436 @default.
- W1551148764 cites W2021193053 @default.
- W1551148764 cites W2026664902 @default.
- W1551148764 cites W2045594979 @default.
- W1551148764 cites W2108033609 @default.
- W1551148764 cites W2109948886 @default.
- W1551148764 cites W2118128813 @default.
- W1551148764 cites W2120113566 @default.
- W1551148764 cites W2129883110 @default.
- W1551148764 cites W2153506782 @default.
- W1551148764 cites W2155487178 @default.
- W1551148764 cites W2167639722 @default.
- W1551148764 cites W2167641173 @default.
- W1551148764 doi "https://doi.org/10.18632/oncotarget.3010" @default.
- W1551148764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4467119" @default.
- W1551148764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25742787" @default.
- W1551148764 hasPublicationYear "2015" @default.
- W1551148764 type Work @default.
- W1551148764 sameAs 1551148764 @default.
- W1551148764 citedByCount "26" @default.
- W1551148764 countsByYear W15511487642015 @default.
- W1551148764 countsByYear W15511487642016 @default.
- W1551148764 countsByYear W15511487642017 @default.
- W1551148764 countsByYear W15511487642018 @default.
- W1551148764 countsByYear W15511487642019 @default.
- W1551148764 countsByYear W15511487642020 @default.
- W1551148764 countsByYear W15511487642021 @default.
- W1551148764 countsByYear W15511487642022 @default.
- W1551148764 countsByYear W15511487642023 @default.
- W1551148764 crossrefType "journal-article" @default.
- W1551148764 hasAuthorship W1551148764A5035009833 @default.
- W1551148764 hasAuthorship W1551148764A5037574721 @default.
- W1551148764 hasAuthorship W1551148764A5043525645 @default.
- W1551148764 hasAuthorship W1551148764A5048010568 @default.
- W1551148764 hasAuthorship W1551148764A5051446250 @default.
- W1551148764 hasAuthorship W1551148764A5061875124 @default.
- W1551148764 hasAuthorship W1551148764A5063574799 @default.
- W1551148764 hasAuthorship W1551148764A5074219370 @default.
- W1551148764 hasAuthorship W1551148764A5085662031 @default.
- W1551148764 hasBestOaLocation W15511487641 @default.
- W1551148764 hasConcept C502942594 @default.
- W1551148764 hasConcept C62478195 @default.
- W1551148764 hasConcept C75217442 @default.
- W1551148764 hasConcept C86803240 @default.
- W1551148764 hasConcept C95444343 @default.
- W1551148764 hasConceptScore W1551148764C502942594 @default.
- W1551148764 hasConceptScore W1551148764C62478195 @default.
- W1551148764 hasConceptScore W1551148764C75217442 @default.
- W1551148764 hasConceptScore W1551148764C86803240 @default.
- W1551148764 hasConceptScore W1551148764C95444343 @default.
- W1551148764 hasIssue "7" @default.
- W1551148764 hasLocation W15511487641 @default.
- W1551148764 hasLocation W15511487642 @default.
- W1551148764 hasLocation W15511487643 @default.
- W1551148764 hasLocation W15511487644 @default.
- W1551148764 hasLocation W15511487645 @default.
- W1551148764 hasLocation W15511487646 @default.
- W1551148764 hasOpenAccess W1551148764 @default.
- W1551148764 hasPrimaryLocation W15511487641 @default.
- W1551148764 hasRelatedWork W1641042124 @default.
- W1551148764 hasRelatedWork W1990804418 @default.
- W1551148764 hasRelatedWork W1993764875 @default.
- W1551148764 hasRelatedWork W2013243191 @default.
- W1551148764 hasRelatedWork W2051339581 @default.
- W1551148764 hasRelatedWork W2082860237 @default.
- W1551148764 hasRelatedWork W2117258802 @default.
- W1551148764 hasRelatedWork W2130076355 @default.
- W1551148764 hasRelatedWork W2151865869 @default.
- W1551148764 hasRelatedWork W4234157524 @default.
- W1551148764 hasVolume "6" @default.
- W1551148764 isParatext "false" @default.
- W1551148764 isRetracted "false" @default.
- W1551148764 magId "1551148764" @default.
- W1551148764 workType "article" @default.