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• W1551173845 abstract "Cancer stem cells (CSC) seem to be resistant to conventional chemoand radiation therapies when compared with non-CSCs. Conventional cytotoxic therapies initially shrink the bulk of a tumor, but fail to eradicate it, resulting in tumor recurrence. Treatment failure may in part be due to the resistance of CSCs to chemotherapy or radiotherapy (Baumann et al., 2008; Eyler & Rich, 2008). Drug or radiation surviving cells (residual tumor cells following treatment) have been shown to contain a higher frequency of putative CSCs in a number of human malignancies. Bao et al. demonstrated that the population of cells enriched for glioma CSCs was dramatically increased by irradiation and that radioresistant gliomas showed an increased percentage of CD133 positive cells (Bao et al., 2006). Tsuchida et al showed that anti-cancer drug treatment increases the side-population fraction (considered CSCs) in cancer cell lines (Tsuchida et al., 2008). Over the past decades, preoperative chemoradiotherapy (CRT) has been established as one approach in the multimodal treatment of several types of gastrointestinal malignancies. In rectal cancer, preoperative CRT followed by surgery has improved sphincter preservation, local pelvic control and survival of patients with locally advanced rectal cancer (Bosset et al., 2006; Guillem et al., 2005). However, disease recurrence (especially for distant metastases) remains the major cause of mortality in these patients (Collette et al., 2007; van den Brink et al., 2004). In rectal cancer, tumor regression grading (TRG) following CRT was determined by quantifying the proportion of residual cancer cells to the stroma of the entire tumor bed on formalin-fixed paraffin embedded (FFPE) specimens. TRG or pathologic response has been shown to predict clinical outcome (disease recurrence or patient survival) of oesophageal (Brucher et al., 2006; Chirieac et al., 2005), gastric (Patel et al., 2007; Rohatgi et al., 2006), or rectal cancer (Rodel et al., 2005) in patients after preoperative CRT followed by surgery, rather than pre-CRT clinical stage. The amount of residual cancer cells after CRT seems to be predictive of disease recurrence and survival in relation to CRT resistance." @default.
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• W1551173845 date "2011-08-01" @default.
• W1551173845 modified "2023-09-23" @default.
• W1551173845 title "Clinical Significance of Putative Cancer Stem Cells in Residual Cancer Cells After Chemoradiotherapy for Rectal Cancer" @default.
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• W1551173845 doi "https://doi.org/10.5772/18324" @default.
• W1551173845 hasPublicationYear "2011" @default.
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