FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551183408> ?p ?o ?g. }

• W1551183408 endingPage "3092" @default.
• W1551183408 startingPage "3086" @default.
• W1551183408 abstract "Abstract Acute lung injury produced by deposition of IgA immune complexes is complement-dependent, neutrophil-independent, oxygen radical-mediated, and may be a result of the formation of the hydroxyl radical (HO) generated directly or indirectly from activated lung macrophages. The current studies were designed to evaluate further the pathophysiologic events that occur after intrapulmonary deposition of IgA immune complexes. Pretreatment of rats with the human recombinant soluble complement receptor-1 resulted in marked attenuation of IgA immune complex-induced lung injury. Intravenous administration of antibody to CD18, but not antibody to CD11b, was highly protective against lung injury. Treatment of animals with either anti-endothelial leukocyte-adhesion molecule-1 or anti-TNF-alpha, both of which were highly protective against IgG immune complex-induced lung injury, had no protective effects in the model of IgA immune complex-induced lung injury. Immunohistochemical analysis revealed up-regulation of the endothelial leukocyte adhesion molecule-1 in the pulmonary vasculature after deposition of IgA immune complexes. This up-regulation was TNF-alpha-dependent. The arginine analog, NG-monomethyl-L-arginine, was highly protective against IgA immune complex-induced lung injury. This protective effect was reversed by the co-presence of L-arginine (but not D-arginine). Protective interventions against IgA immune complex-induced lung injury were inversely correlated with the numbers of macrophages that could be retrieved by lung lavage. These data suggest fundamental differences in the pathogenesis of lung injury after intrapulmonary deposition of IgA immune complexes, as compared with injury caused by deposition of IgG immune complexes. In the latter, neutrophils, intrapulmonary generation of TNF-alpha, and up-regulation of pulmonary vascular endothelial leukocyte-adhesion molecule-1 are required for the full development of lung injury, whereas no such requirements appear in the case of IgA immune complex-induced lung injury. Full expression of IgA immune complex-induced lung injury also appears to require L-arginine, suggesting a possible role for nitric oxide or its derivatives in events ultimately leading to injury." @default.
• W1551183408 created "2016-06-24" @default.
• W1551183408 creator A5002905801 @default.
• W1551183408 creator A5021022677 @default.
• W1551183408 creator A5026915262 @default.
• W1551183408 creator A5030346835 @default.
• W1551183408 creator A5050335917 @default.
• W1551183408 creator A5055326884 @default.
• W1551183408 creator A5062961599 @default.
• W1551183408 date "1992-05-15" @default.
• W1551183408 modified "2023-10-14" @default.
• W1551183408 title "Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine." @default.
• W1551183408 doi "https://doi.org/10.4049/jimmunol.148.10.3086" @default.
• W1551183408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1374449" @default.
• W1551183408 hasPublicationYear "1992" @default.
• W1551183408 type Work @default.
• W1551183408 sameAs 1551183408 @default.
• W1551183408 citedByCount "70" @default.
• W1551183408 countsByYear W15511834082012 @default.
• W1551183408 countsByYear W15511834082014 @default.
• W1551183408 countsByYear W15511834082015 @default.
• W1551183408 countsByYear W15511834082016 @default.
• W1551183408 countsByYear W15511834082018 @default.
• W1551183408 crossrefType "journal-article" @default.
• W1551183408 hasAuthorship W1551183408A5002905801 @default.
• W1551183408 hasAuthorship W1551183408A5021022677 @default.
• W1551183408 hasAuthorship W1551183408A5026915262 @default.
• W1551183408 hasAuthorship W1551183408A5030346835 @default.
• W1551183408 hasAuthorship W1551183408A5050335917 @default.
• W1551183408 hasAuthorship W1551183408A5055326884 @default.
• W1551183408 hasAuthorship W1551183408A5062961599 @default.
• W1551183408 hasBestOaLocation W15511834081 @default.
• W1551183408 hasConcept C126322002 @default.
• W1551183408 hasConcept C159654299 @default.
• W1551183408 hasConcept C16224149 @default.
• W1551183408 hasConcept C171779818 @default.
• W1551183408 hasConcept C185592680 @default.
• W1551183408 hasConcept C203014093 @default.
• W1551183408 hasConcept C2776914184 @default.
• W1551183408 hasConcept C2777714996 @default.
• W1551183408 hasConcept C2778474638 @default.
• W1551183408 hasConcept C71924100 @default.
• W1551183408 hasConcept C8891405 @default.
• W1551183408 hasConceptScore W1551183408C126322002 @default.
• W1551183408 hasConceptScore W1551183408C159654299 @default.
• W1551183408 hasConceptScore W1551183408C16224149 @default.
• W1551183408 hasConceptScore W1551183408C171779818 @default.
• W1551183408 hasConceptScore W1551183408C185592680 @default.
• W1551183408 hasConceptScore W1551183408C203014093 @default.
• W1551183408 hasConceptScore W1551183408C2776914184 @default.
• W1551183408 hasConceptScore W1551183408C2777714996 @default.
• W1551183408 hasConceptScore W1551183408C2778474638 @default.
• W1551183408 hasConceptScore W1551183408C71924100 @default.
• W1551183408 hasConceptScore W1551183408C8891405 @default.
• W1551183408 hasIssue "10" @default.
• W1551183408 hasLocation W15511834081 @default.
• W1551183408 hasLocation W15511834082 @default.
• W1551183408 hasOpenAccess W1551183408 @default.
• W1551183408 hasPrimaryLocation W15511834081 @default.
• W1551183408 hasRelatedWork W1969418017 @default.
• W1551183408 hasRelatedWork W2041901455 @default.
• W1551183408 hasRelatedWork W2103136465 @default.
• W1551183408 hasRelatedWork W2382888825 @default.
• W1551183408 hasRelatedWork W2394658940 @default.
• W1551183408 hasRelatedWork W2519199594 @default.
• W1551183408 hasRelatedWork W2748952813 @default.
• W1551183408 hasRelatedWork W2899084033 @default.
• W1551183408 hasRelatedWork W3005652238 @default.
• W1551183408 hasRelatedWork W4200627258 @default.
• W1551183408 hasVolume "148" @default.
• W1551183408 isParatext "false" @default.
• W1551183408 isRetracted "false" @default.
• W1551183408 magId "1551183408" @default.
• W1551183408 workType "article" @default.