FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551234207> ?p ?o ?g. }

• W1551234207 endingPage "394" @default.
• W1551234207 startingPage "388" @default.
• W1551234207 abstract "Platelet-rich plasma (PRP) contains many growth factors that are involved in tissue regeneration processes. For successful tissue regeneration, protein growth factors require a delivery vehicle for long-term and sustained release to a defect site in order to maintain their bioactivity. Previously, we showed that heparin-conjugated poly(lactic-co-glycolic acid) nanospheres (HCPNs) can provide long-term delivery of growth factors with affinity for heparin. In this study, we hypothesize that treatment of a skin wound with a mixture of PRP and HCPNs would provide long-term delivery of several growth factors contained in PRP to promote the skin wound healing process with preservation of bioactivity. The release of platelet-derived growth factor-BB (PDGF-BB), contained in PRP, from HCPN with fibrin gel (FG) showed a prolonged release period versus a PRP mixture with FG alone (FG-PRP). Also, growth factors released from PRP with HCPN and FG showed sustained human dermal fibroblast growth for 12 days. Full-thickness skin wound treatment in mice with FG-HCPN-PRP resulted in much faster wound closure as well as dermal and epidermal regeneration at day 9 compared with treatment with FG-HCPN or FG-PRP. The enhanced wound healing using FG-HCPN-PRP may be due to the prolonged release not only of PDGF-BB but also of other growth factors in the PRP. The delivered growth factors accelerated angiogenesis at the wound site." @default.
• W1551234207 created "2016-06-24" @default.
• W1551234207 creator A5028979794 @default.
• W1551234207 creator A5055125775 @default.
• W1551234207 date "2014-10-05" @default.
• W1551234207 modified "2023-10-01" @default.
• W1551234207 title "Heparin-Conjugated Poly(Lactic-Co-Glycolic Acid) Nanospheres Enhance Large-Wound Healing by Delivering Growth Factors in Platelet-Rich Plasma" @default.
• W1551234207 cites W1560970554 @default.
• W1551234207 cites W1949832432 @default.
• W1551234207 cites W1959506586 @default.
• W1551234207 cites W1983299207 @default.
• W1551234207 cites W1988794582 @default.
• W1551234207 cites W1995708059 @default.
• W1551234207 cites W2013546498 @default.
• W1551234207 cites W2015273176 @default.
• W1551234207 cites W2026876563 @default.
• W1551234207 cites W2047411956 @default.
• W1551234207 cites W2064853491 @default.
• W1551234207 cites W2066348646 @default.
• W1551234207 cites W2067721580 @default.
• W1551234207 cites W2071566911 @default.
• W1551234207 cites W2076626680 @default.
• W1551234207 cites W2079655979 @default.
• W1551234207 cites W2082640557 @default.
• W1551234207 cites W2087120448 @default.
• W1551234207 cites W2111778166 @default.
• W1551234207 cites W2115514008 @default.
• W1551234207 cites W2122366747 @default.
• W1551234207 cites W4214780281 @default.
• W1551234207 doi "https://doi.org/10.1111/aor.12389" @default.
• W1551234207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25284020" @default.
• W1551234207 hasPublicationYear "2014" @default.
• W1551234207 type Work @default.
• W1551234207 sameAs 1551234207 @default.
• W1551234207 citedByCount "29" @default.
• W1551234207 countsByYear W15512342072015 @default.
• W1551234207 countsByYear W15512342072016 @default.
• W1551234207 countsByYear W15512342072017 @default.
• W1551234207 countsByYear W15512342072018 @default.
• W1551234207 countsByYear W15512342072019 @default.
• W1551234207 countsByYear W15512342072020 @default.
• W1551234207 countsByYear W15512342072021 @default.
• W1551234207 countsByYear W15512342072022 @default.
• W1551234207 countsByYear W15512342072023 @default.
• W1551234207 crossrefType "journal-article" @default.
• W1551234207 hasAuthorship W1551234207A5028979794 @default.
• W1551234207 hasAuthorship W1551234207A5055125775 @default.
• W1551234207 hasConcept C141071460 @default.
• W1551234207 hasConcept C170493617 @default.
• W1551234207 hasConcept C171056886 @default.
• W1551234207 hasConcept C180361614 @default.
• W1551234207 hasConcept C185592680 @default.
• W1551234207 hasConcept C202751555 @default.
• W1551234207 hasConcept C203014093 @default.
• W1551234207 hasConcept C2775920511 @default.
• W1551234207 hasConcept C2775960820 @default.
• W1551234207 hasConcept C2777557582 @default.
• W1551234207 hasConcept C2780076745 @default.
• W1551234207 hasConcept C2780269544 @default.
• W1551234207 hasConcept C2780381497 @default.
• W1551234207 hasConcept C2780394083 @default.
• W1551234207 hasConcept C2780472526 @default.
• W1551234207 hasConcept C2781294074 @default.
• W1551234207 hasConcept C502942594 @default.
• W1551234207 hasConcept C523546767 @default.
• W1551234207 hasConcept C54173615 @default.
• W1551234207 hasConcept C54355233 @default.
• W1551234207 hasConcept C55493867 @default.
• W1551234207 hasConcept C71924100 @default.
• W1551234207 hasConcept C74373430 @default.
• W1551234207 hasConcept C86803240 @default.
• W1551234207 hasConcept C89560881 @default.
• W1551234207 hasConcept C95444343 @default.
• W1551234207 hasConcept C98274493 @default.
• W1551234207 hasConceptScore W1551234207C141071460 @default.
• W1551234207 hasConceptScore W1551234207C170493617 @default.
• W1551234207 hasConceptScore W1551234207C171056886 @default.
• W1551234207 hasConceptScore W1551234207C180361614 @default.
• W1551234207 hasConceptScore W1551234207C185592680 @default.
• W1551234207 hasConceptScore W1551234207C202751555 @default.
• W1551234207 hasConceptScore W1551234207C203014093 @default.
• W1551234207 hasConceptScore W1551234207C2775920511 @default.
• W1551234207 hasConceptScore W1551234207C2775960820 @default.
• W1551234207 hasConceptScore W1551234207C2777557582 @default.
• W1551234207 hasConceptScore W1551234207C2780076745 @default.
• W1551234207 hasConceptScore W1551234207C2780269544 @default.
• W1551234207 hasConceptScore W1551234207C2780381497 @default.
• W1551234207 hasConceptScore W1551234207C2780394083 @default.
• W1551234207 hasConceptScore W1551234207C2780472526 @default.
• W1551234207 hasConceptScore W1551234207C2781294074 @default.
• W1551234207 hasConceptScore W1551234207C502942594 @default.
• W1551234207 hasConceptScore W1551234207C523546767 @default.
• W1551234207 hasConceptScore W1551234207C54173615 @default.
• W1551234207 hasConceptScore W1551234207C54355233 @default.
• W1551234207 hasConceptScore W1551234207C55493867 @default.
• W1551234207 hasConceptScore W1551234207C71924100 @default.
• W1551234207 hasConceptScore W1551234207C74373430 @default.
• W1551234207 hasConceptScore W1551234207C86803240 @default.

• next