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• W1551276164 abstract "Preservation of the integrity of the DNA, carrier of heritage information, is crucial for cell survival. Altered genetic information could lead to major perturbations in cell organization, function and proliferation of cancer cells. Because cancer cells are highly proliferative with high number of replication, DNA was the first clinically used anti-cancer therapeutic target with the drugs directly (intercalators/alkylating drugs) or indirectly (micro-tubules, topoisomerases inhibitors, modifiers of histone acetylation...) targeting DNA. Despite the actual development of targeted chemotherapies (against membrane receptors, kinases, the proteasome,...), direct DNA targeting drugs still represent a major part of the actual anticancer pharmacopeia in terms of total prescriptions and efficacy. Compounds mainly bind DNA in three different ways: non-covalent (fitting in major or minor grooves), intercalation between two successive base pairs, or covalent bonding to a base, and generally lead to a stabilization of the DNA double helix. Only a few number from intercalating and alkylating families destabilizes the DNA helix. Cytotoxic effects of alkylating agents (used/developed for chemotherapy or from carcinogens) are strongly attenuated by the cellular DNA repair processes. Optimal use of DNA alkylating drugs in therapy requires a clear understanding of their DNA repair processes. Similarly, knowing how cells cope with the carcinogensinduced DNA damages is of major interest regarding health in our actual society, so prompt to use chemical compounds insufficiently studied for long term toxicities and sometimes eventually identified as carcinogens (food and industries). DNA repair processes infer with both those Yin and Yang aspects of alkylating compounds using different machineries: base excision repair (BER); nucleotide excision repair (NER: long/short-patch, transcriptioncoupled/global genome); mismatch repair (MMR); homologous recombination (HR) or nonhomologous end-joining (NHEJ). Fanconi anemia (FA) repair acts as a coordinator of those repair pathways (Moldovan & D'Andrea, 2009). Since there are yet various complete reviews on DNA repair processes in the literature, the present review will focus on the repair process of DNA destabilizing compounds." @default.
• W1551276164 created "2016-06-24" @default.
• W1551276164 creator A5050461936 @default.
• W1551276164 creator A5063938256 @default.
• W1551276164 creator A5064770152 @default.
• W1551276164 creator A5075576447 @default.
• W1551276164 date "2011-10-26" @default.
• W1551276164 modified "2023-09-26" @default.
• W1551276164 title "DNA Helix Destabilization by Alkylating Agents: From Covalent Bonding to DNA Repair" @default.
• W1551276164 cites W1480983598 @default.
• W1551276164 cites W1503517711 @default.
• W1551276164 cites W1513901790 @default.
• W1551276164 cites W1519991935 @default.
• W1551276164 cites W1573750334 @default.
• W1551276164 cites W1593442063 @default.
• W1551276164 cites W1863440278 @default.
• W1551276164 cites W1872551000 @default.
• W1551276164 cites W1963995039 @default.
• W1551276164 cites W1965118572 @default.
• W1551276164 cites W1967258994 @default.
• W1551276164 cites W1967287923 @default.
• W1551276164 cites W1967405783 @default.
• W1551276164 cites W1968101185 @default.
• W1551276164 cites W1969005524 @default.
• W1551276164 cites W1971339396 @default.
• W1551276164 cites W1974665834 @default.
• W1551276164 cites W1976678888 @default.
• W1551276164 cites W1977571930 @default.
• W1551276164 cites W1980458711 @default.
• W1551276164 cites W1981259804 @default.
• W1551276164 cites W1981384318 @default.
• W1551276164 cites W1982266992 @default.
• W1551276164 cites W1984260352 @default.
• W1551276164 cites W1984694497 @default.
• W1551276164 cites W1987646951 @default.
• W1551276164 cites W1988398583 @default.
• W1551276164 cites W1988619957 @default.
• W1551276164 cites W1991484258 @default.
• W1551276164 cites W1993384720 @default.
• W1551276164 cites W1994305568 @default.
• W1551276164 cites W1995840404 @default.
• W1551276164 cites W1995970704 @default.
• W1551276164 cites W1997558986 @default.
• W1551276164 cites W1999737902 @default.
• W1551276164 cites W2001942134 @default.
• W1551276164 cites W2004899809 @default.
• W1551276164 cites W2005723165 @default.
• W1551276164 cites W2007709159 @default.
• W1551276164 cites W2007775504 @default.
• W1551276164 cites W2009797037 @default.
• W1551276164 cites W2012555512 @default.
• W1551276164 cites W2014389626 @default.
• W1551276164 cites W2014758051 @default.
• W1551276164 cites W2017407107 @default.
• W1551276164 cites W2018169190 @default.
• W1551276164 cites W2018184839 @default.
• W1551276164 cites W2019098558 @default.
• W1551276164 cites W2020069709 @default.
• W1551276164 cites W2021911915 @default.
• W1551276164 cites W2022631460 @default.
• W1551276164 cites W2024090065 @default.
• W1551276164 cites W2024257426 @default.
• W1551276164 cites W2025515800 @default.
• W1551276164 cites W2025983590 @default.
• W1551276164 cites W2026771072 @default.
• W1551276164 cites W2028130329 @default.
• W1551276164 cites W2028176167 @default.
• W1551276164 cites W2028265989 @default.
• W1551276164 cites W2028649695 @default.
• W1551276164 cites W2028973234 @default.
• W1551276164 cites W2030935068 @default.
• W1551276164 cites W2031547464 @default.
• W1551276164 cites W2031723581 @default.
• W1551276164 cites W2033271892 @default.
• W1551276164 cites W2033932638 @default.
• W1551276164 cites W2035376552 @default.
• W1551276164 cites W2035440732 @default.
• W1551276164 cites W2036854945 @default.
• W1551276164 cites W2037288471 @default.
• W1551276164 cites W2039031053 @default.
• W1551276164 cites W2040859770 @default.
• W1551276164 cites W2041854593 @default.
• W1551276164 cites W2043814428 @default.
• W1551276164 cites W2049372916 @default.
• W1551276164 cites W2051723868 @default.
• W1551276164 cites W2055325103 @default.
• W1551276164 cites W2059890127 @default.
• W1551276164 cites W2060086971 @default.
• W1551276164 cites W2061972729 @default.
• W1551276164 cites W2062130291 @default.
• W1551276164 cites W2062618205 @default.
• W1551276164 cites W2063431624 @default.
• W1551276164 cites W2065600610 @default.
• W1551276164 cites W2066386477 @default.
• W1551276164 cites W2066669756 @default.
• W1551276164 cites W2068373996 @default.
• W1551276164 cites W2072871721 @default.
• W1551276164 cites W2075215418 @default.
• W1551276164 cites W2076091293 @default.
• W1551276164 cites W2079157510 @default.

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