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- W1551293312 abstract "Adequate dietary fiber intakes, particularly fiber from cereal grains, have been associated with a low risk of colorectal cancer (1). Wheat bran appears to protect against tumor development more consistently than other sources of plant fiber in a number of experimental colon cancer studies (2–4). Several hypotheses have been established to explain the link between wheat bran and cancer prevention, including the increase of overall GI transit time, dilution of carcinogenic compounds, release of short-chain fatty acids, and promotion of tumor suppressor signaling, among others (5–8). However, the experimental evidence by using different fiber sources or different doses on colon cancer prevention is controversial (9,10). Especially, a study conducted in theTakemoto laboratory showed that antitumor activities ofwheat bran from various wheat cultivars were significantly different even when fiber content was equal (11). Lignans are a group of the phytochemicals that are composed of phenylpropane dimer linked with a 1,4-diarylbutane structure by b-b bonds. Figure 16.1 shows the chemical structure of a few prominent lignans. Lignans not only present abundantly in flaxseed but also present in various grains such as wheat (12). In wheat, lignans are located in thepericarpandaleurone layerswith thehighest concentration inwheat bran (13). The main lignan in wheat bran is SDG. Table 16.1 lists the contents of SDG in flaxseed, wheat bran, and some other selected plant foods. As one group of secondary metabolites, lignans are synthesized via phenylpropanoid pathway. However, the completed biosynthetic pathways to the lignans in wheat are not clear. The Lewis laboratory from the Washington State University" @default.
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- W1551293312 date "2007-06-21" @default.
- W1551293312 modified "2023-10-03" @default.
- W1551293312 title "Wheat Antioxidants" @default.
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- W1551293312 doi "https://doi.org/10.1002/9780470228333" @default.
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