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- W1551330261 abstract "Summary The kinetics of inactivation of C′1 in human serum treated with Na 3 EDTA are reported. The extent of reaction was dependent on time and temperature but was insensitive to pH and ionic strength. Complete inactivation of C′1, following first order kinetics after an initial accelerated phase, was achieved by incubating serum at unadjusted pH and ionic strength with 10 -2 to 5 × 10 -2 M Na 3 EDTA at 45°C for 4–5 hr. The specific effect of Ca ++ in stabilizing C′1 was shown by using MgNa EDTA and CaNa EDTA under the same conditions. Although partial inactivation of other components of complement occurred in some experiments, the primary effect of Ca ++ -depletion was on C′1. The activity of C′1 could not be restored after complete inactivation had occurred but partial restoration was possible after partial inactivation. Sera depleted of C′1 by treatment with Na 3 EDTA (R1-EDTA) were tested as reagents for measurement of C′1 in a human serum pool and in a purified fraction. When prepared under carefully controlled conditions of concentration of Na 3 EDTA, temperature, time, and ratio of surface area to serum volume, R1-EDTA compared favorably with conventional R1 prepared by dialysis as a reagent for such titrations." @default.
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- W1551330261 date "1959-10-01" @default.
- W1551330261 modified "2023-09-23" @default.
- W1551330261 title "Further studies on the effect of calcium ions on the first component of human complement (C'1)." @default.
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