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• W1551336670 abstract "The P2X 7 receptor has recently been described as a marker for lung alveolar epithelial type I cells. Here, we demonstrate both the expression of P2X 7 protein and its partition into lipid rafts in the mouse lung alveolar epithelial cell line E10. A significant degree of colocalization was observed between P2X 7 and the raft marker protein Caveolin‐1; also, P2X 7 protein was associated with caveolae. A marked reduction in P2X 7 immunoreactivity was observed in lung sections prepared from Caveolin‐1‐knockout mice, indicating that Caveolin‐1 expression was required for full expression of P2X 7 protein. Indeed, suppression of Caveolin‐1 protein expression in E10 cells using short hairpin RNAs resulted in a large reduction in P2X 7 protein expression. Our data demonstrate a potential interaction between P2X 7 protein and Caveolin‐1 in lipid rafts, and provide a basis for further functional and biochemical studies to probe the physiologic significance of this interaction." @default.
• W1551336670 created "2016-06-24" @default.
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• W1551336670 date "2007-05-17" @default.
• W1551336670 modified "2023-10-17" @default.
• W1551336670 title "Caveolin-1 influences P2X7 receptor expression and localization in mouse lung alveolar epithelial cells" @default.
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• W1551336670 doi "https://doi.org/10.1111/j.1742-4658.2007.05830.x" @default.
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