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- W155134865 abstract "Research Article1 September 1994free access Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells. T. Lernbecher T. Lernbecher Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author B. Kistler B. Kistler Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author T. Wirth T. Wirth Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author T. Lernbecher T. Lernbecher Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author B. Kistler B. Kistler Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author T. Wirth T. Wirth Zentrum für Molekulare Biologie Heidelberg, Germany. Search for more papers by this author Author Information T. Lernbecher1, B. Kistler1 and T. Wirth1 1Zentrum für Molekulare Biologie Heidelberg, Germany. The EMBO Journal (1994)13:4060-4069https://doi.org/10.1002/j.1460-2075.1994.tb06723.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The kappa B-motif is an important regulatory element both for constitutive lymphoid-specific as well as ubiquitous inducible transcriptional activity. We have shown previously that different members of the NF-kappa B/Rel family of transcription factors are responsible for these distinct functions. Whereas the p65/RelA protein is involved in inducible kappa B-dependent transcription, RelB is associated with constitutive activity in lymphoid cells. Here we have addressed the question of how RelB is constitutively activated in lymphoid cells. We demonstrate that this is achieved by two different mechanisms. Expression of relB as determined by measurement of stable RNA and protein levels is significantly enhanced in lymphoid organs compared with non-lymphoid organs. However, these observed differences in absolute amounts of RNA and protein would not suffice to explain the dramatic differences that are apparent at the level of active DNA binding complexes in extracts from the respective organs. We have therefore analyzed the interaction of RelB complexes with the I kappa B-alpha inhibitor protein. Our results show that RelB-containing complexes present in lymphoid extracts are much less susceptible to inhibition by I kappa B-alpha than RelA- or RelB-containing complexes from non-lymphoid cells. This difference might be due to post-translational modifications of the RelB protein or interaction with a lymphoid-specific cofactor for RelB. Previous ArticleNext Article Volume 13Issue 171 September 1994In this issue RelatedDetailsLoading ..." @default.
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- W155134865 title "Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells." @default.
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- W155134865 doi "https://doi.org/10.1002/j.1460-2075.1994.tb06723.x" @default.
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