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- W1551435895 abstract "textabstractBone marrow transplantation (BMT) is the intravenous infusion of hemopoietic stern cellsand progenitor cells with the aim to fe-establish normal marrow function and immunity in arecipient with damaged or defective bone marrow (BM). Although some have traced theorigin of this procedure to the end of the past century, when patients were given bone marroworally as trcatment for hematologic disorders, a more realistic starting point is a 1939 reportof a patient who received intravenously 18 ml of marrow from his brother as a treatment foraplastic anemia. The beginning of modern BMT can be traced to experiments showing thatrodents could be protected against lethal hemopoietic injury by the intravenous infusion ofBM. The extensive studies on BMT in animal models, the subsequent identification oftransplantation antigens and the development of techniques for freezing and thawinghemopoietic cells laid the groundwork for the difficult and time-consuming clinical trials thathave brought BMT to its present, albeit imperfect, state. Few areas in medicine illustrateswell the development of a new treatment through the close interaction between advances inlaboratory and in clinical science.In the late 1960s, the first successful allogeneic bone marrow transplantations have beenperformed which led to the gradual acceptance of this therapy. Autologous BMT was firstsuccessfully employed to cure patients with lymphoma in the late 1970s, and its lise becamewidespread in the 1980s." @default.
- W1551435895 created "2016-06-24" @default.
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- W1551435895 date "1995-04-12" @default.
- W1551435895 modified "2023-09-27" @default.
- W1551435895 title "Graft-versus-leukemia : applicable in the treatment of leukemia with bone marrow transplantation? : preclinical studies in rat models relevant for human acute leukemia" @default.
- W1551435895 hasPublicationYear "1995" @default.
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