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- W1551467614 endingPage "407" @default.
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- W1551467614 abstract "Initiation of transcription by RNA polymerase II on TATA box-containing promoters requires the obligatory assembly of a complex between the TATA box binding protein (TBP) and the TATA element in DNA. This complex forms a platform on which the remaining general transcription factors are assembled and bound. As the TATA elements are primarily composed of A • T basepairs, the sequence specificity dictated by the TATA box consensus sequence (TATA@A@X) is not easily explained by direct readout alone. Nor is it clear from structural data alone how protein-DNA interaction causes the striking structural properties observed in all the crystal structures of TBP complexes. These include the ~90° bend in DNA, and untwisting of the DNA helix throughout the eight basepairs contacted by TBP. We review here the current answers to these mechanistic questions, including the sources of DNA sequence selectivity in TBP-DNA complexes, in light of sequence-dependent properties of the various TATA boxes. Results from specific experiments, as well as from molecular dynamics simulations and energy calculations, are used to arrive at the proposed mechanisms that rationalize both structural and kinetic data. A surprising role of structural flexibility of TBP in these mechanisms is revealed from molecular dynamics simulations and recent experimental data." @default.
- W1551467614 created "2016-06-24" @default.
- W1551467614 creator A5017231817 @default.
- W1551467614 creator A5019384637 @default.
- W1551467614 date "2001-01-01" @default.
- W1551467614 modified "2023-09-27" @default.
- W1551467614 title "Protein-DNA interactions in the initiation of transcription: The Role of Flexibility and Dynamics of the TATA Recognition Sequence and the TATA Box Binding Protein" @default.
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