Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551491567> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1551491567 endingPage "42" @default.
- W1551491567 startingPage "1337" @default.
- W1551491567 abstract "When 1-beta-D-arabinofuranosylcytosine (ara-C), 25 mg/m2, is infused over 3 h together with tetrahydrouridine (THU) at 10 to 350 mg/m2 to heavily pretreated patients with solid tumors, Michaelis-Menten type kinetic values are observed with leveling off of delta area under the curve, delta ara-C levels at 3 h, and delta total body clearance after 150 mg/m2 of THU. When the ara-C dose was increased to 50, 75, and 100 mg/m2 coinfusion of 250 or 350 mg/m2 of THU significantly increased plasma ara-C at peak and area under the curve. In contrast, total body clearance and volume of distribution decreased significantly. At 100 mg/m2 of ara-C coinfused with high doses of THU, i.e., at 350 mg/m2, the pharmacokinetics of plasma ara-C was changed from a biphasic decay of plasma ara-C at peaks (control) to a curve similar or identical to a monophasic curve, indicating that THU not only inhibits deamination but also changes the distribution of ara-C. This combination provides plasma ara-C levels (greater than or equal to 10 microM) comparable to high dose ara-C at 1 g/m2. Such plasma ara-C levels are considered to be sufficient for saturation of the kinases catalyzing the production of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate. This reduced ara-C dose necessary to achieve saturation of kinases also reduces plasma 1-beta-D-arabinofuranosyluracil levels substantially. Toxicity of this combination was predominantly confined to bone marrow and gastrointestinal toxicity." @default.
- W1551491567 created "2016-06-24" @default.
- W1551491567 creator A5004888325 @default.
- W1551491567 creator A5011632607 @default.
- W1551491567 creator A5014103813 @default.
- W1551491567 creator A5021159601 @default.
- W1551491567 creator A5041006769 @default.
- W1551491567 creator A5047151300 @default.
- W1551491567 creator A5060343841 @default.
- W1551491567 creator A5062945280 @default.
- W1551491567 creator A5063325521 @default.
- W1551491567 creator A5072443682 @default.
- W1551491567 creator A5080292051 @default.
- W1551491567 creator A5082571324 @default.
- W1551491567 date "1988-03-01" @default.
- W1551491567 modified "2023-09-26" @default.
- W1551491567 title "Effect of tetrahydrouridine on the clinical pharmacology of 1-beta-D-arabinofuranosylcytosine when both drugs are coinfused over three hours." @default.
- W1551491567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3342412" @default.
- W1551491567 hasPublicationYear "1988" @default.
- W1551491567 type Work @default.
- W1551491567 sameAs 1551491567 @default.
- W1551491567 citedByCount "13" @default.
- W1551491567 countsByYear W15514915672016 @default.
- W1551491567 countsByYear W15514915672018 @default.
- W1551491567 crossrefType "journal-article" @default.
- W1551491567 hasAuthorship W1551491567A5004888325 @default.
- W1551491567 hasAuthorship W1551491567A5011632607 @default.
- W1551491567 hasAuthorship W1551491567A5014103813 @default.
- W1551491567 hasAuthorship W1551491567A5021159601 @default.
- W1551491567 hasAuthorship W1551491567A5041006769 @default.
- W1551491567 hasAuthorship W1551491567A5047151300 @default.
- W1551491567 hasAuthorship W1551491567A5060343841 @default.
- W1551491567 hasAuthorship W1551491567A5062945280 @default.
- W1551491567 hasAuthorship W1551491567A5063325521 @default.
- W1551491567 hasAuthorship W1551491567A5072443682 @default.
- W1551491567 hasAuthorship W1551491567A5080292051 @default.
- W1551491567 hasAuthorship W1551491567A5082571324 @default.
- W1551491567 hasConcept C110121322 @default.
- W1551491567 hasConcept C112705442 @default.
- W1551491567 hasConcept C126322002 @default.
- W1551491567 hasConcept C134306372 @default.
- W1551491567 hasConcept C139254425 @default.
- W1551491567 hasConcept C145782189 @default.
- W1551491567 hasConcept C181199279 @default.
- W1551491567 hasConcept C185592680 @default.
- W1551491567 hasConcept C33923547 @default.
- W1551491567 hasConcept C55493867 @default.
- W1551491567 hasConcept C71924100 @default.
- W1551491567 hasConcept C98274493 @default.
- W1551491567 hasConceptScore W1551491567C110121322 @default.
- W1551491567 hasConceptScore W1551491567C112705442 @default.
- W1551491567 hasConceptScore W1551491567C126322002 @default.
- W1551491567 hasConceptScore W1551491567C134306372 @default.
- W1551491567 hasConceptScore W1551491567C139254425 @default.
- W1551491567 hasConceptScore W1551491567C145782189 @default.
- W1551491567 hasConceptScore W1551491567C181199279 @default.
- W1551491567 hasConceptScore W1551491567C185592680 @default.
- W1551491567 hasConceptScore W1551491567C33923547 @default.
- W1551491567 hasConceptScore W1551491567C55493867 @default.
- W1551491567 hasConceptScore W1551491567C71924100 @default.
- W1551491567 hasConceptScore W1551491567C98274493 @default.
- W1551491567 hasIssue "5" @default.
- W1551491567 hasLocation W15514915671 @default.
- W1551491567 hasOpenAccess W1551491567 @default.
- W1551491567 hasPrimaryLocation W15514915671 @default.
- W1551491567 hasRelatedWork W1946606054 @default.
- W1551491567 hasRelatedWork W1968025310 @default.
- W1551491567 hasRelatedWork W1987470123 @default.
- W1551491567 hasRelatedWork W1996305828 @default.
- W1551491567 hasRelatedWork W2264246004 @default.
- W1551491567 hasRelatedWork W2406588624 @default.
- W1551491567 hasRelatedWork W2463077557 @default.
- W1551491567 hasRelatedWork W2467642788 @default.
- W1551491567 hasRelatedWork W2783095880 @default.
- W1551491567 hasRelatedWork W3120625362 @default.
- W1551491567 hasVolume "48" @default.
- W1551491567 isParatext "false" @default.
- W1551491567 isRetracted "false" @default.
- W1551491567 magId "1551491567" @default.
- W1551491567 workType "article" @default.