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- W1551601636 abstract "In placental mammals some 100-200 genes are expressed only from the paternal or the maternal allele. This peculiar expression pattern is the result of genomic imprinting, an epigenetic process by which the male and the female germ line confer a parent-of-origin specific mark (imprint) on certain chromosomal regions. The size of imprinted regions ranges from several kilobases to several megabases. The process of genomic imprinting is controlled by cis-acting imprinting centers (IC) and trans-acting factors. IC mutations affect the establishment or maintenance of genomic imprints and hence the expression of all imprinted genes controlled by this IC. Imprinting defects play a causal role in several recognizable syndromes." @default.
- W1551601636 created "2016-06-24" @default.
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- W1551601636 date "2008-01-01" @default.
- W1551601636 modified "2023-10-09" @default.
- W1551601636 title "Chapter 8 Genomic Imprinting and Imprinting Defects in Humans" @default.
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- W1551601636 doi "https://doi.org/10.1016/s0065-2660(07)00008-9" @default.
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