Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551639690> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1551639690 endingPage "918" @default.
- W1551639690 startingPage "908" @default.
- W1551639690 abstract "Abstract Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease is a relevant mouse model of multiple sclerosis. Demyelination is linked to persistent TMEV infection of the central nervous system and characterized by perivascular inflammatory mononuclear infiltrates and primary demyelination. Myelin damage is a T cell-dependent process and susceptibility correlates with the temporal development of chronic virus-specific delayed-type hypersensitivity (DTH) responses. Our previous results have shown that inflammatory processes mediated by Th1 cells specific for a determinant(s) on virus capsid protein 2 (VP2) play a major immunopathologic role in SJL/J mice. This study identifies a 13 amino acid peptide on VP2 (VP2(74-86)) as the immunodominant T cell epitope in TMEV-infected and -immunized SJL/J mice, and demonstrates the ability of that sequence to prime for the majority of the SJL/J DTH T cell response to intact TMEV. The importance of T cell responses to this epitope in the demyelinating process was illustrated by experiments in which SJL/J mice displayed an increased incidence and accelerated onset of clinical disease after peripheral immunization with a fusion protein containing VP2(74-84) before intracerebral infection with a suboptimal dose of the BeAn strain of TMEV. Identification of this immunopathologic TMEV T cell epitope will be critically important for delineation of the mechanisms of T cell-mediated myelin damage and for potential use to prevent and/or treat TMEV-induced demyelinating disease via the induction of epitope-specific tolerance." @default.
- W1551639690 created "2016-06-24" @default.
- W1551639690 creator A5016036240 @default.
- W1551639690 creator A5016727284 @default.
- W1551639690 creator A5017239432 @default.
- W1551639690 creator A5033876610 @default.
- W1551639690 creator A5048940729 @default.
- W1551639690 creator A5049981359 @default.
- W1551639690 creator A5077504487 @default.
- W1551639690 date "1994-01-15" @default.
- W1551639690 modified "2023-10-16" @default.
- W1551639690 title "Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice." @default.
- W1551639690 doi "https://doi.org/10.4049/jimmunol.152.2.908" @default.
- W1551639690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7904291" @default.
- W1551639690 hasPublicationYear "1994" @default.
- W1551639690 type Work @default.
- W1551639690 sameAs 1551639690 @default.
- W1551639690 citedByCount "77" @default.
- W1551639690 countsByYear W15516396902012 @default.
- W1551639690 countsByYear W15516396902013 @default.
- W1551639690 countsByYear W15516396902014 @default.
- W1551639690 countsByYear W15516396902015 @default.
- W1551639690 countsByYear W15516396902016 @default.
- W1551639690 crossrefType "journal-article" @default.
- W1551639690 hasAuthorship W1551639690A5016036240 @default.
- W1551639690 hasAuthorship W1551639690A5016727284 @default.
- W1551639690 hasAuthorship W1551639690A5017239432 @default.
- W1551639690 hasAuthorship W1551639690A5033876610 @default.
- W1551639690 hasAuthorship W1551639690A5048940729 @default.
- W1551639690 hasAuthorship W1551639690A5049981359 @default.
- W1551639690 hasAuthorship W1551639690A5077504487 @default.
- W1551639690 hasBestOaLocation W15516396901 @default.
- W1551639690 hasConcept C159047783 @default.
- W1551639690 hasConcept C159654299 @default.
- W1551639690 hasConcept C169760540 @default.
- W1551639690 hasConcept C195616568 @default.
- W1551639690 hasConcept C203014093 @default.
- W1551639690 hasConcept C2522874641 @default.
- W1551639690 hasConcept C2776090121 @default.
- W1551639690 hasConcept C2777899865 @default.
- W1551639690 hasConcept C2778531937 @default.
- W1551639690 hasConcept C2778609137 @default.
- W1551639690 hasConcept C2780640218 @default.
- W1551639690 hasConcept C529278444 @default.
- W1551639690 hasConcept C86803240 @default.
- W1551639690 hasConcept C8891405 @default.
- W1551639690 hasConceptScore W1551639690C159047783 @default.
- W1551639690 hasConceptScore W1551639690C159654299 @default.
- W1551639690 hasConceptScore W1551639690C169760540 @default.
- W1551639690 hasConceptScore W1551639690C195616568 @default.
- W1551639690 hasConceptScore W1551639690C203014093 @default.
- W1551639690 hasConceptScore W1551639690C2522874641 @default.
- W1551639690 hasConceptScore W1551639690C2776090121 @default.
- W1551639690 hasConceptScore W1551639690C2777899865 @default.
- W1551639690 hasConceptScore W1551639690C2778531937 @default.
- W1551639690 hasConceptScore W1551639690C2778609137 @default.
- W1551639690 hasConceptScore W1551639690C2780640218 @default.
- W1551639690 hasConceptScore W1551639690C529278444 @default.
- W1551639690 hasConceptScore W1551639690C86803240 @default.
- W1551639690 hasConceptScore W1551639690C8891405 @default.
- W1551639690 hasIssue "2" @default.
- W1551639690 hasLocation W15516396901 @default.
- W1551639690 hasLocation W15516396902 @default.
- W1551639690 hasOpenAccess W1551639690 @default.
- W1551639690 hasPrimaryLocation W15516396901 @default.
- W1551639690 hasRelatedWork W1531320013 @default.
- W1551639690 hasRelatedWork W1538307588 @default.
- W1551639690 hasRelatedWork W2015190767 @default.
- W1551639690 hasRelatedWork W2029273446 @default.
- W1551639690 hasRelatedWork W2033335271 @default.
- W1551639690 hasRelatedWork W2035373989 @default.
- W1551639690 hasRelatedWork W2167530110 @default.
- W1551639690 hasRelatedWork W2405941604 @default.
- W1551639690 hasRelatedWork W3139976826 @default.
- W1551639690 hasRelatedWork W3151166576 @default.
- W1551639690 hasVolume "152" @default.
- W1551639690 isParatext "false" @default.
- W1551639690 isRetracted "false" @default.
- W1551639690 magId "1551639690" @default.
- W1551639690 workType "article" @default.