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- W1551697811 abstract "Publisher Summary The goal of proteomics is the identification, characterization, and quantification of all the proteins in an organism. This is a formidable task because of the large number of proteins in a cell and the wide range of protein amounts. The chapter discusses how simulations can be used both to plan proteomics experiments and to aid in the evaluation of the experimental results. In a typical proteomics experiment, the starting point is the enrichment of proteins of interests from an organism. The proteins in this mixture are then separated by means of chromatography or electrophoresis. Following the protein separation, the fractions of interest are digested with a proteolytic enzyme to generate a set of peptides for further analysis. A final step of chromatography may be required if the resulting mixture of proteolytic peptides is expected to be too complex for direct mass analysis. For good quantification, proteins and/or peptides are often labeled with stable isotopes in cells or at a later stage of the sample processing. Finally, the peptides are analyzed with mass spectrometry (MS), to obtain the masses of the proteolytic peptides, as well as the masses of their fragments. The selection and combination of these methods is critical for a successful experiment. Protein identification is performed by comparing the experimental mass data to protein sequences." @default.
- W1551697811 created "2016-06-24" @default.
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- W1551697811 date "2005-01-01" @default.
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- W1551697811 title "Chapter 13 Simulation as a tool for optimizing proteome analysis" @default.
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- W1551697811 doi "https://doi.org/10.1016/s0166-526x(05)46013-4" @default.
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