FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551725906> ?p ?o ?g. }

• W1551725906 endingPage "3636" @default.
• W1551725906 startingPage "3636" @default.
• W1551725906 abstract "The MDR1 gene is an attractive candidate gene for the pathogenesis of inflammatory bowel disease (IBD) and perhaps response to therapy, with evidences at both functional and genetic levels. Its product, the P-glycoprotein (P-gp) functions as a transmembrane efflux pump thus influencing disposition and response of many drugs, some of whom (i.e. glucocorticoids) central to IBD therapy. In addition P-gp is highly expressed in many epithelial surfaces, included gastrointestinal tract (G-I) with a putative role in decreasing the absorption of endogenous or exogenous toxins, and perhaps host-bacteria interaction. Many genetic variations of MDR1 gene has been described and in some instances evidences for different P-gp expression as well drugs metabolism have been provided. However data are often conflicting due to genetic heterogeneity and different methodologies employed. Perhaps the greatest piece of evidence of the physiological importance of P-gp in the G-I tract has come from the description of the mdr1 knock-out mice model, which develops a spontaneous colitis in a specific pathogen-free environment. Studies investigating MDR1 gene polymorphism and predisposition to IBD have also shown conflicting results, owing to the known difficulties in complex diseases, especially when the supposed genetic contribution is weak. In this study we have undertaken a meta-analysis of the available findings obtained with two SNPs polymorphism (C3435T and G2677T/A) in IBD; a significant association of 3435T allele and 3435TT genotype has been found with UC (OR = 1.17, P = 0.003 and OR = 1.36, P = 0.017, respectively). In contrast no association with CD and the G2677T/A polymorphism could be demonstrated." @default.
• W1551725906 created "2016-06-24" @default.
• W1551725906 creator A5005084792 @default.
• W1551725906 creator A5015267957 @default.
• W1551725906 creator A5040818753 @default.
• W1551725906 creator A5052681875 @default.
• W1551725906 creator A5061802269 @default.
• W1551725906 creator A5078649698 @default.
• W1551725906 date "2006-01-01" @default.
• W1551725906 modified "2023-10-17" @default.
• W1551725906 title "Multidrug resistance 1 gene in inflammatory bowel disease: A meta-analysis" @default.
• W1551725906 cites W123422070 @default.
• W1551725906 cites W1505376713 @default.
• W1551725906 cites W1526872663 @default.
• W1551725906 cites W1548348015 @default.
• W1551725906 cites W1565203547 @default.
• W1551725906 cites W1567907251 @default.
• W1551725906 cites W1577781821 @default.
• W1551725906 cites W16118829 @default.
• W1551725906 cites W1912531397 @default.
• W1551725906 cites W1964470226 @default.
• W1551725906 cites W1964909312 @default.
• W1551725906 cites W1967278221 @default.
• W1551725906 cites W1972856183 @default.
• W1551725906 cites W1975261946 @default.
• W1551725906 cites W1977235697 @default.
• W1551725906 cites W1978096998 @default.
• W1551725906 cites W1981301171 @default.
• W1551725906 cites W1982105713 @default.
• W1551725906 cites W1984820569 @default.
• W1551725906 cites W1985153028 @default.
• W1551725906 cites W1989134116 @default.
• W1551725906 cites W1991886667 @default.
• W1551725906 cites W1999382644 @default.
• W1551725906 cites W2000683024 @default.
• W1551725906 cites W2002345475 @default.
• W1551725906 cites W2002800880 @default.
• W1551725906 cites W2013047801 @default.
• W1551725906 cites W2015956279 @default.
• W1551725906 cites W2018652769 @default.
• W1551725906 cites W2021759214 @default.
• W1551725906 cites W2024131514 @default.
• W1551725906 cites W2026786730 @default.
• W1551725906 cites W2027475037 @default.
• W1551725906 cites W2028533496 @default.
• W1551725906 cites W2035927996 @default.
• W1551725906 cites W2037621239 @default.
• W1551725906 cites W2039667371 @default.
• W1551725906 cites W2048397780 @default.
• W1551725906 cites W2049268060 @default.
• W1551725906 cites W2050497622 @default.
• W1551725906 cites W2052330087 @default.
• W1551725906 cites W2054458932 @default.
• W1551725906 cites W2056897801 @default.
• W1551725906 cites W2057755081 @default.
• W1551725906 cites W2059584690 @default.
• W1551725906 cites W2060385396 @default.
• W1551725906 cites W2062903328 @default.
• W1551725906 cites W2067797700 @default.
• W1551725906 cites W2068865770 @default.
• W1551725906 cites W2069388748 @default.
• W1551725906 cites W2078877172 @default.
• W1551725906 cites W2086478906 @default.
• W1551725906 cites W2086931156 @default.
• W1551725906 cites W2090841445 @default.
• W1551725906 cites W2090910729 @default.
• W1551725906 cites W2098938825 @default.
• W1551725906 cites W2099651827 @default.
• W1551725906 cites W2102276800 @default.
• W1551725906 cites W2102937624 @default.
• W1551725906 cites W2109083028 @default.
• W1551725906 cites W2118342649 @default.
• W1551725906 cites W2123596072 @default.
• W1551725906 cites W2126262050 @default.
• W1551725906 cites W2128240839 @default.
• W1551725906 cites W2128566951 @default.
• W1551725906 cites W2131584305 @default.
• W1551725906 cites W2140496932 @default.
• W1551725906 cites W2141597037 @default.
• W1551725906 cites W2158246924 @default.
• W1551725906 cites W2163636362 @default.
• W1551725906 cites W2171279314 @default.
• W1551725906 cites W2198182531 @default.
• W1551725906 cites W2269527315 @default.
• W1551725906 cites W2330149118 @default.
• W1551725906 cites W25713858 @default.
• W1551725906 cites W3113099567 @default.
• W1551725906 cites W321996270 @default.
• W1551725906 cites W4253613276 @default.
• W1551725906 cites W47219713 @default.
• W1551725906 doi "https://doi.org/10.3748/wjg.v12.i23.3636" @default.
• W1551725906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4087454" @default.
• W1551725906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16773678" @default.
• W1551725906 hasPublicationYear "2006" @default.
• W1551725906 type Work @default.
• W1551725906 sameAs 1551725906 @default.
• W1551725906 citedByCount "138" @default.
• W1551725906 countsByYear W15517259062012 @default.

• next