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- W1551736336 abstract "Feeding of [1-13C]propionate to cultures of Streptomyces erythreus gave erythromycin A and B labeled at C-1, 3, 5, 7, 9, 11, and 13, as established by 13C NMR analysis of the derived 2'- benzoate esters. Incorporation of [2-13C]propionate labeled C-2, 4, 6, 8, 10, 12, and 20 while feeding of ethyl [2,3-13C2]succinate, an in vivo precursor of [2,2' -13C2]methylmalonate, gave rise to seven pairs of enhanced and coupled doublets in the spectra of labeled erythromycin A and B benzoate Subsequent incorporation of [1-18O2, 1-13C]propionate and 13C NMR analysis established the presence of excess 18O at C- 1, 3, 5, 9, 11, and 13 in both erythromycins A and B, as evidenced by the corresponding isotopically shifted 13C18O peaks. These results establish that in the biosynthesis of erythromycin all the O atoms of the initial aglycone, 6-deoxyerythronolide B (3) originate directly from propionate." @default.
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- W1551736336 date "1983-01-01" @default.
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- W1551736336 title "Macrolide biosynthesis—II" @default.
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- W1551736336 doi "https://doi.org/10.1016/s0040-4020(01)88655-5" @default.
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