FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W15517436> ?p ?o ?g. }

• W15517436 endingPage "72" @default.
• W15517436 startingPage "60" @default.
• W15517436 abstract "We have studied at the ultrastructural level the presence of manganese (Mn) in rat basal ganglia, which are target regions of the brain for Mn toxicity. The rats underwent a moderate level of Mn exposure induced per os for 13 weeks. Mn was detected by means of electron spectroscopy imaging (ESI) and electron energy-loss spectroscopy (EELS) analyses on perfusion fixed samples embedded in resin. While no significant contamination by exogenous Mn occurred during the processing procedures, less than 50% of endogenous Mn was lost during fixation and dehydration of the brain samples. The residual Mn ions in the samples appeared as discrete particles, localized in selected sub-cellular organelles in a cell, suggesting that no significant translocation had occurred in the surrounding area. In control rats, the Mn sub-cellular localization and relative content were the same in neurons and astrocytes of rat striatum and globus pallidus: the Mn level was highest in the heterochromatin and in the nucleolus, intermediate in the cytoplasm, and lowest in the mitochondria (p < 0.001). After chronic Mn treatment, while no ultrastructural damage was detected in the neurons and glial cells, the largest rate of Mn increase was noted in the mitochondria of astrocytes (+700%), an intermediate rate in the mitochondria of neurons (+200%), and the lowest rate in the nuclei (+100%) of neurons and astrocytes; the Mn level in the cytoplasm appeared unchanged. EELS analysis detected the specific spectra of Mn L2,3 (peak at ΔE = 665 eV) in such organelles, confirming the findings of ESI. Although a consistent loss of Mn occurred during the processing of tissue samples, ESI and EELS can be useful methods for localization of endogenous Mn in embedded tissues. The high rate of Mn sequestration in the mitochondria of astrocytes in vivo may partly explain the outstanding capacity of astrocytes to accumulate Mn, and their early dysfunction in Mn neurotoxicity. The high level of Mn in the heterochromatin and nucleoli of neurons and astrocytes in basal conditions and its further increase after Mn overload should provide insight into new avenues of investigating the role of Mn in the normal brain and a baseline for future Mn toxicity studies." @default.
• W15517436 created "2016-06-24" @default.
• W15517436 creator A5000795732 @default.
• W15517436 creator A5021429755 @default.
• W15517436 creator A5025244730 @default.
• W15517436 creator A5027712485 @default.
• W15517436 creator A5029553123 @default.
• W15517436 creator A5047197126 @default.
• W15517436 creator A5055945496 @default.
• W15517436 creator A5065091264 @default.
• W15517436 creator A5083212112 @default.
• W15517436 creator A5091359537 @default.
• W15517436 date "2008-01-01" @default.
• W15517436 modified "2023-09-29" @default.
• W15517436 title "Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats" @default.
• W15517436 cites W1248810041 @default.
• W15517436 cites W1500635024 @default.
• W15517436 cites W1587060900 @default.
• W15517436 cites W1638870030 @default.
• W15517436 cites W1713124107 @default.
• W15517436 cites W1892104498 @default.
• W15517436 cites W1965307530 @default.
• W15517436 cites W1990343106 @default.
• W15517436 cites W1994132312 @default.
• W15517436 cites W1994748186 @default.
• W15517436 cites W1996885362 @default.
• W15517436 cites W1998861841 @default.
• W15517436 cites W2000232989 @default.
• W15517436 cites W2001538543 @default.
• W15517436 cites W2007702111 @default.
• W15517436 cites W2008072540 @default.
• W15517436 cites W2020925155 @default.
• W15517436 cites W2021185620 @default.
• W15517436 cites W2022025789 @default.
• W15517436 cites W2023222913 @default.
• W15517436 cites W2027188754 @default.
• W15517436 cites W2039142811 @default.
• W15517436 cites W2040407175 @default.
• W15517436 cites W2045760568 @default.
• W15517436 cites W2048191736 @default.
• W15517436 cites W2048960021 @default.
• W15517436 cites W2049161948 @default.
• W15517436 cites W2067517387 @default.
• W15517436 cites W2070898641 @default.
• W15517436 cites W2071786082 @default.
• W15517436 cites W2072304064 @default.
• W15517436 cites W2072424259 @default.
• W15517436 cites W2074948983 @default.
• W15517436 cites W2083725583 @default.
• W15517436 cites W2087330407 @default.
• W15517436 cites W2091269830 @default.
• W15517436 cites W2092077944 @default.
• W15517436 cites W2134004958 @default.
• W15517436 cites W2135282721 @default.
• W15517436 cites W2143081505 @default.
• W15517436 cites W2412261528 @default.
• W15517436 cites W2415971737 @default.
• W15517436 cites W4230182397 @default.
• W15517436 doi "https://doi.org/10.1016/j.neuro.2007.09.001" @default.
• W15517436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17936361" @default.
• W15517436 hasPublicationYear "2008" @default.
• W15517436 type Work @default.
• W15517436 sameAs 15517436 @default.
• W15517436 citedByCount "104" @default.
• W15517436 countsByYear W155174362012 @default.
• W15517436 countsByYear W155174362013 @default.
• W15517436 countsByYear W155174362014 @default.
• W15517436 countsByYear W155174362015 @default.
• W15517436 countsByYear W155174362016 @default.
• W15517436 countsByYear W155174362017 @default.
• W15517436 countsByYear W155174362018 @default.
• W15517436 countsByYear W155174362019 @default.
• W15517436 countsByYear W155174362020 @default.
• W15517436 countsByYear W155174362021 @default.
• W15517436 countsByYear W155174362022 @default.
• W15517436 countsByYear W155174362023 @default.
• W15517436 crossrefType "journal-article" @default.
• W15517436 hasAuthorship W15517436A5000795732 @default.
• W15517436 hasAuthorship W15517436A5021429755 @default.
• W15517436 hasAuthorship W15517436A5025244730 @default.
• W15517436 hasAuthorship W15517436A5027712485 @default.
• W15517436 hasAuthorship W15517436A5029553123 @default.
• W15517436 hasAuthorship W15517436A5047197126 @default.
• W15517436 hasAuthorship W15517436A5055945496 @default.
• W15517436 hasAuthorship W15517436A5065091264 @default.
• W15517436 hasAuthorship W15517436A5083212112 @default.
• W15517436 hasAuthorship W15517436A5091359537 @default.
• W15517436 hasConcept C105702510 @default.
• W15517436 hasConcept C12554922 @default.
• W15517436 hasConcept C134018914 @default.
• W15517436 hasConcept C168240541 @default.
• W15517436 hasConcept C178790620 @default.
• W15517436 hasConcept C185592680 @default.
• W15517436 hasConcept C190062978 @default.
• W15517436 hasConcept C2778187257 @default.
• W15517436 hasConcept C2779491297 @default.
• W15517436 hasConcept C2780062018 @default.
• W15517436 hasConcept C2780278869 @default.

• next