Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551781210> ?p ?o ?g. }
- W1551781210 endingPage "703" @default.
- W1551781210 startingPage "696" @default.
- W1551781210 abstract "Glial cells that produce and respond to various cytokines mediate inflammatory processes in the brain. Here, we show that oncostatin M (OSM) and interleukin-1 (IL-1) regulate the expression of plasminogen activator inhibitor-1 (PAI-1) and urokinase-type plasminogen activator (uPA) in human astrocytes. Using the PAI-1 reporter constructs we show that the -58 to -51 proximal element mediates activation by both cytokines. This element is already bound by c-fos/c-jun heterodimers in unstimulated astrocytes, and treatment with cytokine strongly stimulates both expression of c-fos and binding of c-fos/c-jun heterodimers. In addition, IL-1 activates an inhibitory mechanism that down-regulates PAI-1 expression after longer exposure to this cytokine. Overexpression of dominant-negative signal transducer and activator of transcription-1 (STAT1), STAT3, STAT5 and inhibitor of nuclear factor-kappaB (IkappaB) suppressed OSM/IL-1-induced expression of the PAI-1 reporter construct. We conclude that OSM and IL-1 regulate the PAI-1 gene expression via up-regulating c-fos levels and subsequent binding of c-fos/c-jun heterodimers to the proximal element of the PAI-1 gene." @default.
- W1551781210 created "2016-06-24" @default.
- W1551781210 creator A5005558401 @default.
- W1551781210 creator A5008575543 @default.
- W1551781210 creator A5021007196 @default.
- W1551781210 creator A5031587148 @default.
- W1551781210 creator A5044017005 @default.
- W1551781210 creator A5047515959 @default.
- W1551781210 creator A5075736542 @default.
- W1551781210 date "2002-10-17" @default.
- W1551781210 modified "2023-10-18" @default.
- W1551781210 title "Mechanism of plasminogen activator inhibitor-1 regulation by oncostatin M and interleukin-1 in human astrocytes" @default.
- W1551781210 cites W1496109170 @default.
- W1551781210 cites W1560711427 @default.
- W1551781210 cites W1562744925 @default.
- W1551781210 cites W1585344925 @default.
- W1551781210 cites W1692854040 @default.
- W1551781210 cites W1919471009 @default.
- W1551781210 cites W1992141146 @default.
- W1551781210 cites W1997253884 @default.
- W1551781210 cites W1997289355 @default.
- W1551781210 cites W2004563262 @default.
- W1551781210 cites W2008369621 @default.
- W1551781210 cites W2008494281 @default.
- W1551781210 cites W2008686569 @default.
- W1551781210 cites W2014669590 @default.
- W1551781210 cites W2015358516 @default.
- W1551781210 cites W2015945020 @default.
- W1551781210 cites W2017389700 @default.
- W1551781210 cites W2017605183 @default.
- W1551781210 cites W2034974668 @default.
- W1551781210 cites W2045680380 @default.
- W1551781210 cites W2061903251 @default.
- W1551781210 cites W2061991508 @default.
- W1551781210 cites W2062614652 @default.
- W1551781210 cites W2066818645 @default.
- W1551781210 cites W2069300364 @default.
- W1551781210 cites W2078475797 @default.
- W1551781210 cites W2080499279 @default.
- W1551781210 cites W2085214769 @default.
- W1551781210 cites W2091272253 @default.
- W1551781210 cites W2108684428 @default.
- W1551781210 cites W2117327528 @default.
- W1551781210 cites W2117491739 @default.
- W1551781210 cites W2124914285 @default.
- W1551781210 cites W2152266604 @default.
- W1551781210 cites W2154697657 @default.
- W1551781210 cites W2166365300 @default.
- W1551781210 cites W2323429156 @default.
- W1551781210 cites W289221030 @default.
- W1551781210 cites W4299881772 @default.
- W1551781210 doi "https://doi.org/10.1046/j.1471-4159.2002.01163.x" @default.
- W1551781210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4567031" @default.
- W1551781210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12390531" @default.
- W1551781210 hasPublicationYear "2002" @default.
- W1551781210 type Work @default.
- W1551781210 sameAs 1551781210 @default.
- W1551781210 citedByCount "38" @default.
- W1551781210 countsByYear W15517812102012 @default.
- W1551781210 countsByYear W15517812102013 @default.
- W1551781210 countsByYear W15517812102017 @default.
- W1551781210 countsByYear W15517812102019 @default.
- W1551781210 countsByYear W15517812102020 @default.
- W1551781210 countsByYear W15517812102022 @default.
- W1551781210 crossrefType "journal-article" @default.
- W1551781210 hasAuthorship W1551781210A5005558401 @default.
- W1551781210 hasAuthorship W1551781210A5008575543 @default.
- W1551781210 hasAuthorship W1551781210A5021007196 @default.
- W1551781210 hasAuthorship W1551781210A5031587148 @default.
- W1551781210 hasAuthorship W1551781210A5044017005 @default.
- W1551781210 hasAuthorship W1551781210A5047515959 @default.
- W1551781210 hasAuthorship W1551781210A5075736542 @default.
- W1551781210 hasBestOaLocation W15517812101 @default.
- W1551781210 hasConcept C104317684 @default.
- W1551781210 hasConcept C11988809 @default.
- W1551781210 hasConcept C134018914 @default.
- W1551781210 hasConcept C153911025 @default.
- W1551781210 hasConcept C171958077 @default.
- W1551781210 hasConcept C185592680 @default.
- W1551781210 hasConcept C203014093 @default.
- W1551781210 hasConcept C2777003663 @default.
- W1551781210 hasConcept C2777667943 @default.
- W1551781210 hasConcept C2778690821 @default.
- W1551781210 hasConcept C2778923194 @default.
- W1551781210 hasConcept C2779679481 @default.
- W1551781210 hasConcept C2780675426 @default.
- W1551781210 hasConcept C55493867 @default.
- W1551781210 hasConcept C62478195 @default.
- W1551781210 hasConcept C86803240 @default.
- W1551781210 hasConcept C88045685 @default.
- W1551781210 hasConcept C95444343 @default.
- W1551781210 hasConceptScore W1551781210C104317684 @default.
- W1551781210 hasConceptScore W1551781210C11988809 @default.
- W1551781210 hasConceptScore W1551781210C134018914 @default.
- W1551781210 hasConceptScore W1551781210C153911025 @default.
- W1551781210 hasConceptScore W1551781210C171958077 @default.
- W1551781210 hasConceptScore W1551781210C185592680 @default.
- W1551781210 hasConceptScore W1551781210C203014093 @default.