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- W1551812335 abstract "Neural transplantation is applicable in the treatment of Huntington's disease (HD). At this time, there is only preliminary evidence of safety, tolerability, and efficacy of fetal striatal transplantation for the treatment of HD. The safety profile may differ adversely from similar transplant programs for the treatment of Parkinson's disease, because of the atrophy associated with HD that may predispose patients to the development of subdural hematomas after surgically induced cerebrospinal fluid (CSF) loss. Although graft survival has been demonstrated at autopsy, there is significant gliosis associated with late-stage HD, which may make transplantation in late-stage patients less favorable. Human fetal striatal grafts in both rodent models and patients with HD are capable of receiving appropriate neuritic in growth from the host brain. It remains unproven if striatal grafts in patients with HD are similarly capable of extending projections over the distances necessary to reach appropriate target areas, as seen in animal allograft transplant models of HD. There is currently no agreement on the optimal way to dissect human fetal tissue for transplantation purposes." @default.
- W1551812335 created "2016-06-24" @default.
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- W1551812335 date "2000-01-01" @default.
- W1551812335 modified "2023-10-15" @default.
- W1551812335 title "Chapter 18 Neural transplantation for the treatment of Huntington's disease" @default.
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- W1551812335 doi "https://doi.org/10.1016/s0079-6123(00)27019-2" @default.
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