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- W1551831696 abstract "Neuroinflammation comprises a feature of many neurological disorders that is accompanied by the activation of glial cells and the release of pro-inflammatory cytokines and chemokines. Such activation is a normal response oriented to protect neural tissue and it is mainly regulated by microglia and astroglia. However, excessive and chronic activation of glia may lead to neurotoxicity and may be harmful for neural tissue. The ovarian hormone oestradiol exerts protective actions in the central nervous system that, at least in part, are mediated by a reduction of reactive gliosis. Several selective oestrogen receptor modulators may also exert neuroprotective effects by controlling glial inflammatory responses. Thus, tamoxifen and raloxifene decrease the inflammatory response caused by lipopolysaccharide, a bacterial endotoxin, in mouse and rat microglia cells in vitro. Tamoxifen and raloxifene are also able to reduce microglia activation in the brain of male and female rats in vivo after the peripheral administration of lipopolysaccharide. In addition, tamoxifen decreases the microglia inflammatory response induced by irradiation. Furthermore, treatment with tamoxifen and raloxifene resulted in a significant reduction of the number of reactive astrocytes in the hippocampus of young, middle-aged and older female rats after a stab wound injury. Tamoxifen, raloxifene and the new selective oestrogen receptor modulators ospemifene and bazedoxifene decrease the expression and release of interleukine-6 and interferon-γ inducible protein-10 in cultured astrocytes exposed to lipopolysaccharide. Ospemifene and bazedoxifene exert anti-inflammatory effects in astrocytes by a mechanism involving classical oestrogen receptors and the inhibition of nuclear factor-kappa B p65 transactivation. These data suggest that oestrogenic compounds are candidates to counteract brain inflammation under neurodegenerative conditions by targeting the production and release of pro-inflammatory molecules by glial cells." @default.
- W1551831696 created "2016-06-24" @default.
- W1551831696 creator A5057589065 @default.
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- W1551831696 creator A5075695575 @default.
- W1551831696 creator A5084691625 @default.
- W1551831696 date "2011-12-20" @default.
- W1551831696 modified "2023-10-13" @default.
- W1551831696 title "Selective Oestrogen Receptor Modulators Decrease the Inflammatory Response of Glial Cells" @default.
- W1551831696 cites W148009547 @default.
- W1551831696 cites W1563590122 @default.
- W1551831696 cites W1573339245 @default.
- W1551831696 cites W1575257247 @default.
- W1551831696 cites W1594425991 @default.
- W1551831696 cites W1841952425 @default.
- W1551831696 cites W1874568289 @default.
- W1551831696 cites W1962177146 @default.
- W1551831696 cites W1968085067 @default.
- W1551831696 cites W1971446180 @default.
- W1551831696 cites W1972534236 @default.
- W1551831696 cites W1973434266 @default.
- W1551831696 cites W1973563466 @default.
- W1551831696 cites W1974997673 @default.
- W1551831696 cites W1975111111 @default.
- W1551831696 cites W1975172876 @default.
- W1551831696 cites W1977604451 @default.
- W1551831696 cites W1978611085 @default.
- W1551831696 cites W1981072854 @default.
- W1551831696 cites W1981988940 @default.
- W1551831696 cites W1985064654 @default.
- W1551831696 cites W1989692357 @default.
- W1551831696 cites W1991785432 @default.
- W1551831696 cites W1995797542 @default.
- W1551831696 cites W1998101636 @default.
- W1551831696 cites W1998333056 @default.
- W1551831696 cites W1999890575 @default.
- W1551831696 cites W1999896243 @default.
- W1551831696 cites W2002257605 @default.
- W1551831696 cites W2003581234 @default.
- W1551831696 cites W2005519211 @default.
- W1551831696 cites W2005907346 @default.
- W1551831696 cites W2006292576 @default.
- W1551831696 cites W2008880717 @default.
- W1551831696 cites W2009102898 @default.
- W1551831696 cites W2013397493 @default.
- W1551831696 cites W2013755949 @default.
- W1551831696 cites W2016436821 @default.
- W1551831696 cites W2017364016 @default.
- W1551831696 cites W2019615335 @default.
- W1551831696 cites W2020476951 @default.
- W1551831696 cites W2020891576 @default.
- W1551831696 cites W2023239820 @default.
- W1551831696 cites W2023983558 @default.
- W1551831696 cites W2024337137 @default.
- W1551831696 cites W2026464698 @default.
- W1551831696 cites W2027286379 @default.
- W1551831696 cites W2027548273 @default.
- W1551831696 cites W2027639859 @default.
- W1551831696 cites W2028155268 @default.
- W1551831696 cites W2030496214 @default.
- W1551831696 cites W2034119678 @default.
- W1551831696 cites W2036232268 @default.
- W1551831696 cites W2039871782 @default.
- W1551831696 cites W2040665941 @default.
- W1551831696 cites W2041938813 @default.
- W1551831696 cites W2042197302 @default.
- W1551831696 cites W2044945941 @default.
- W1551831696 cites W2047286951 @default.
- W1551831696 cites W2048105028 @default.
- W1551831696 cites W2051638429 @default.
- W1551831696 cites W2051947267 @default.
- W1551831696 cites W2052678277 @default.
- W1551831696 cites W2054110130 @default.
- W1551831696 cites W2056596444 @default.
- W1551831696 cites W2058623137 @default.
- W1551831696 cites W2059289119 @default.
- W1551831696 cites W2063165012 @default.
- W1551831696 cites W2063735028 @default.
- W1551831696 cites W2067536104 @default.
- W1551831696 cites W2069905837 @default.
- W1551831696 cites W2070440733 @default.
- W1551831696 cites W2070454626 @default.
- W1551831696 cites W2076870890 @default.
- W1551831696 cites W2077915411 @default.
- W1551831696 cites W2078577857 @default.
- W1551831696 cites W2078787220 @default.
- W1551831696 cites W2078865976 @default.
- W1551831696 cites W2079320514 @default.
- W1551831696 cites W2081279308 @default.
- W1551831696 cites W2081655354 @default.
- W1551831696 cites W2083293065 @default.
- W1551831696 cites W2084594676 @default.
- W1551831696 cites W2085419073 @default.
- W1551831696 cites W2088221213 @default.
- W1551831696 cites W2094046759 @default.
- W1551831696 cites W2094660330 @default.
- W1551831696 cites W2098833893 @default.