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- W1551832642 abstract "Pharmacogenetics have been touted as the future of personalized medicine where genetic biomarkers will guide therapeutic approach. The currently approved thienopyridines, prasugrel and clopidogrel, are prodrugs requiring conversion to active metabolite through the cytochrome P450 system. Genetic variation has been associated with the pharmacokinetic, pharmacodynamic, and clinical response to clopidogrel, but not to prasugrel. This review aims to summarize the recent pharmacogenetic findings associated with the response to thienopyridine treatment. Additionally, considerations for the incorporation of genetic biomarkers into clinical practice will be discussed in the context of thienopyridines." @default.
- W1551832642 created "2016-06-24" @default.
- W1551832642 creator A5038207584 @default.
- W1551832642 date "2011-08-31" @default.
- W1551832642 modified "2023-09-27" @default.
- W1551832642 title "Pharmacogenetics and pharmacogenomics of thienopyridines: clinically relevant?" @default.
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- W1551832642 doi "https://doi.org/10.1111/j.1472-8206.2011.00983.x" @default.
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