Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551963417> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W1551963417 abstract "Abstract : The specific hypothesis was that women who have selected polymorphic variants in genes that predispose them to poorer repair of DNA damage will have greater breast cancer risk. Polymorphisms in base excision repair (xRCCl), nucleotide excision repair (XPD, XPC), double-strand break repair (XRCC3, Rad5l, LIG4) and checkpoint-control (CDKN2A) genes were investigated. A secondary hypothesis was that risk may be further accentuated by lifestyle-related exposures to carcinogens or oxidants. A nested case control study of 612 matched pairs was conducted within the NYU Women's Health Study, a prospective study of over 14,000 healthy women aged 35-65 who were enrolled in the study during 1985-91. Genotyping was performed using RFLP. Statistical analyses were controlled for ethnicity, age, and various risk factors for breast cancer. There was a statistically significant increase in breast cancer risk for women who had the homozygous variant genotype for the XPC-PAT+ polymorphism (OR=l.41, 95% CI: 1.04-1.91). Further analyses suggested that women with the variant allele had an 80% greater (p=O.09) breast cancer risk associated with smoking and 70% greater (p=O.06) for alcohol consumption than those who were wild type. The XRCC3 Thr24l-Met substitution also showed a suggestive association with breast cancer risk." @default.
- W1551963417 created "2016-06-24" @default.
- W1551963417 creator A5003714181 @default.
- W1551963417 date "2002-06-01" @default.
- W1551963417 modified "2023-09-28" @default.
- W1551963417 title "Breast Cancer Susceptibility and DNA Damage/Repair" @default.
- W1551963417 doi "https://doi.org/10.21236/ada413358" @default.
- W1551963417 hasPublicationYear "2002" @default.
- W1551963417 type Work @default.
- W1551963417 sameAs 1551963417 @default.
- W1551963417 citedByCount "0" @default.
- W1551963417 crossrefType "report" @default.
- W1551963417 hasAuthorship W1551963417A5003714181 @default.
- W1551963417 hasConcept C104317684 @default.
- W1551963417 hasConcept C104451858 @default.
- W1551963417 hasConcept C121608353 @default.
- W1551963417 hasConcept C126322002 @default.
- W1551963417 hasConcept C134935766 @default.
- W1551963417 hasConcept C13514818 @default.
- W1551963417 hasConcept C135763542 @default.
- W1551963417 hasConcept C143998085 @default.
- W1551963417 hasConcept C153209595 @default.
- W1551963417 hasConcept C2776071976 @default.
- W1551963417 hasConcept C2779755913 @default.
- W1551963417 hasConcept C2780265364 @default.
- W1551963417 hasConcept C31467283 @default.
- W1551963417 hasConcept C501734568 @default.
- W1551963417 hasConcept C530470458 @default.
- W1551963417 hasConcept C54355233 @default.
- W1551963417 hasConcept C71924100 @default.
- W1551963417 hasConcept C86803240 @default.
- W1551963417 hasConceptScore W1551963417C104317684 @default.
- W1551963417 hasConceptScore W1551963417C104451858 @default.
- W1551963417 hasConceptScore W1551963417C121608353 @default.
- W1551963417 hasConceptScore W1551963417C126322002 @default.
- W1551963417 hasConceptScore W1551963417C134935766 @default.
- W1551963417 hasConceptScore W1551963417C13514818 @default.
- W1551963417 hasConceptScore W1551963417C135763542 @default.
- W1551963417 hasConceptScore W1551963417C143998085 @default.
- W1551963417 hasConceptScore W1551963417C153209595 @default.
- W1551963417 hasConceptScore W1551963417C2776071976 @default.
- W1551963417 hasConceptScore W1551963417C2779755913 @default.
- W1551963417 hasConceptScore W1551963417C2780265364 @default.
- W1551963417 hasConceptScore W1551963417C31467283 @default.
- W1551963417 hasConceptScore W1551963417C501734568 @default.
- W1551963417 hasConceptScore W1551963417C530470458 @default.
- W1551963417 hasConceptScore W1551963417C54355233 @default.
- W1551963417 hasConceptScore W1551963417C71924100 @default.
- W1551963417 hasConceptScore W1551963417C86803240 @default.
- W1551963417 hasLocation W15519634171 @default.
- W1551963417 hasOpenAccess W1551963417 @default.
- W1551963417 hasPrimaryLocation W15519634171 @default.
- W1551963417 hasRelatedWork W2010335397 @default.
- W1551963417 hasRelatedWork W2028203395 @default.
- W1551963417 hasRelatedWork W2033241257 @default.
- W1551963417 hasRelatedWork W2079700038 @default.
- W1551963417 hasRelatedWork W2103580054 @default.
- W1551963417 hasRelatedWork W2104242293 @default.
- W1551963417 hasRelatedWork W2125602466 @default.
- W1551963417 hasRelatedWork W2129678741 @default.
- W1551963417 hasRelatedWork W2134814911 @default.
- W1551963417 hasRelatedWork W2143794443 @default.
- W1551963417 hasRelatedWork W2154460209 @default.
- W1551963417 hasRelatedWork W2165172136 @default.
- W1551963417 hasRelatedWork W2186162938 @default.
- W1551963417 hasRelatedWork W2329780578 @default.
- W1551963417 hasRelatedWork W2434108206 @default.
- W1551963417 hasRelatedWork W2514366564 @default.
- W1551963417 hasRelatedWork W2768114486 @default.
- W1551963417 hasRelatedWork W2955348964 @default.
- W1551963417 hasRelatedWork W3035951804 @default.
- W1551963417 hasRelatedWork W3047593575 @default.
- W1551963417 isParatext "false" @default.
- W1551963417 isRetracted "false" @default.
- W1551963417 magId "1551963417" @default.
- W1551963417 workType "report" @default.