FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1551983874> ?p ?o ?g. }

• W1551983874 endingPage "2536" @default.
• W1551983874 startingPage "2529" @default.
• W1551983874 abstract "We have previously described DNA-dependent protein kinase (DNA-PKcs) mutations in horses and dogs that result in deficits in V(D)J recombination, DNA repair, and SCID. In this paper, we document substantial developmental growth defects in DNA-PKcs-deficient dogs that are not apparent in SCID mice. Fibroblast cell strains derived from either fetal or adult SCID dogs proliferate poorly in culture and undergo premature replicative senescence, somewhat reminiscent of cells derived from Ku-deficient mice. A limited number of animals have been immune reconstituted (by bone marrow transplantation) so that they can be maintained in a normal environment for long periods. Several of these animals have developed conditions associated with premature ageing at 2-3 years of age, roughly 20% of their expected lifespan. These conditions include intestinal malabsorption and primary neural cell neoplasia. These results suggest that DNA-PKcs deficiency is not tolerated equally in all species, perhaps providing insight into why DNA-PKcs deficiency has not been observed in humans. Finally, this study demonstrates the feasibility of maintaining SCID dogs for extended periods of time and documents their utility for bone marrow transplantation studies and as hosts for the propagation of xenografts. In sum, SCID dogs may present researchers with new possibilities for the development of animal models of human disease." @default.
• W1551983874 created "2016-06-24" @default.
• W1551983874 creator A5001804592 @default.
• W1551983874 creator A5013130893 @default.
• W1551983874 creator A5032755720 @default.
• W1551983874 creator A5033432440 @default.
• W1551983874 creator A5034516584 @default.
• W1551983874 creator A5035430209 @default.
• W1551983874 creator A5041018139 @default.
• W1551983874 creator A5059680633 @default.
• W1551983874 creator A5072636454 @default.
• W1551983874 creator A5075690931 @default.
• W1551983874 creator A5083918871 @default.
• W1551983874 creator A5086112000 @default.
• W1551983874 date "2009-08-15" @default.
• W1551983874 modified "2023-10-02" @default.
• W1551983874 title "SCID Dogs: Similar Transplant Potential but Distinct Intra-Uterine Growth Defects and Premature Replicative Senescence Compared with SCID Mice" @default.
• W1551983874 cites W104404459 @default.
• W1551983874 cites W1529935140 @default.
• W1551983874 cites W1541682222 @default.
• W1551983874 cites W1660787335 @default.
• W1551983874 cites W1907438453 @default.
• W1551983874 cites W1974224154 @default.
• W1551983874 cites W1979699797 @default.
• W1551983874 cites W1983276186 @default.
• W1551983874 cites W1988225111 @default.
• W1551983874 cites W1988845313 @default.
• W1551983874 cites W1999012527 @default.
• W1551983874 cites W2007491974 @default.
• W1551983874 cites W2007668115 @default.
• W1551983874 cites W2009364489 @default.
• W1551983874 cites W2015273182 @default.
• W1551983874 cites W2017501208 @default.
• W1551983874 cites W2019501970 @default.
• W1551983874 cites W2021211280 @default.
• W1551983874 cites W2023912146 @default.
• W1551983874 cites W2025008138 @default.
• W1551983874 cites W2034657890 @default.
• W1551983874 cites W2038794308 @default.
• W1551983874 cites W2043431835 @default.
• W1551983874 cites W2053926251 @default.
• W1551983874 cites W2082446466 @default.
• W1551983874 cites W2089190692 @default.
• W1551983874 cites W2091060354 @default.
• W1551983874 cites W2102512189 @default.
• W1551983874 cites W2103007290 @default.
• W1551983874 cites W2104549243 @default.
• W1551983874 cites W2104908670 @default.
• W1551983874 cites W2109456034 @default.
• W1551983874 cites W2117240918 @default.
• W1551983874 cites W2118494034 @default.
• W1551983874 cites W2145788413 @default.
• W1551983874 cites W2154508650 @default.
• W1551983874 cites W2158820560 @default.
• W1551983874 cites W2160204816 @default.
• W1551983874 cites W2161690264 @default.
• W1551983874 cites W2162623265 @default.
• W1551983874 cites W2173547083 @default.
• W1551983874 cites W88099035 @default.
• W1551983874 doi "https://doi.org/10.4049/jimmunol.0801406" @default.
• W1551983874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4047667" @default.
• W1551983874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19635917" @default.
• W1551983874 hasPublicationYear "2009" @default.
• W1551983874 type Work @default.
• W1551983874 sameAs 1551983874 @default.
• W1551983874 citedByCount "8" @default.
• W1551983874 countsByYear W15519838742012 @default.
• W1551983874 countsByYear W15519838742013 @default.
• W1551983874 countsByYear W15519838742014 @default.
• W1551983874 countsByYear W15519838742015 @default.
• W1551983874 countsByYear W15519838742018 @default.
• W1551983874 countsByYear W15519838742020 @default.
• W1551983874 countsByYear W15519838742022 @default.
• W1551983874 crossrefType "journal-article" @default.
• W1551983874 hasAuthorship W1551983874A5001804592 @default.
• W1551983874 hasAuthorship W1551983874A5013130893 @default.
• W1551983874 hasAuthorship W1551983874A5032755720 @default.
• W1551983874 hasAuthorship W1551983874A5033432440 @default.
• W1551983874 hasAuthorship W1551983874A5034516584 @default.
• W1551983874 hasAuthorship W1551983874A5035430209 @default.
• W1551983874 hasAuthorship W1551983874A5041018139 @default.
• W1551983874 hasAuthorship W1551983874A5059680633 @default.
• W1551983874 hasAuthorship W1551983874A5072636454 @default.
• W1551983874 hasAuthorship W1551983874A5075690931 @default.
• W1551983874 hasAuthorship W1551983874A5083918871 @default.
• W1551983874 hasAuthorship W1551983874A5086112000 @default.
• W1551983874 hasBestOaLocation W15519838741 @default.
• W1551983874 hasConcept C104317684 @default.
• W1551983874 hasConcept C126322002 @default.
• W1551983874 hasConcept C134935766 @default.
• W1551983874 hasConcept C203014093 @default.
• W1551983874 hasConcept C2779468541 @default.
• W1551983874 hasConcept C2911091166 @default.
• W1551983874 hasConcept C502942594 @default.
• W1551983874 hasConcept C522857546 @default.
• W1551983874 hasConcept C54355233 @default.
• W1551983874 hasConcept C552990157 @default.
• W1551983874 hasConcept C64241487 @default.

• next