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- W1552238162 abstract "The effects of eliminating cycling precursors by in vivo administration of high doses of hydroxyurea (HU) in populations of mouse spleen T lymphocytes were studied by membrane immunofluorescence identifying mature Thy 1+, Lyt 2- and Lyt 2+ cell populations and mitogen-induced T-cell growth factor (TCGF) production or reactivity to TCGF. HU treatment results in a sharp decrease in the total number of T cells in mouse spleen, indicating that about 50% of peripheral splenic T lymphocytes have a short survival time in vivo. This depletion is more marked for Lyt 2+ cells than for Lyt 2- cells. The decay of TCGF-reactive spleen cells after drug administration is similar to that of the overall spleen T-cell population. Conversely, production of TCGF induced by concanavalin A is predominantly affected by HU treatment, indicating a shorter life span of the cell(s) involved in TCGF production." @default.
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- W1552238162 date "1984-04-01" @default.
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- W1552238162 title "Effects of Hydroxyurea on Concanavalin-A-Induced T-Cell Proliferation." @default.
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- W1552238162 doi "https://doi.org/10.1111/j.1365-3083.1984.tb00936.x" @default.
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