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- W1552297218 abstract "Human T lymphocytes, rerosetted with sheep erythrocytes in the presence of adenosine, yield two subpopulations: a major one (ER), still capable of forming E rosettes; and a minor nonrosetting (ES) one. The two subpopulations differed in their proliferative responses to various mitogens. ER cells responded well to galactose oxidase (GO), soybean agglutinin (SBA), and phytohemagglutinin (PHA) but responded poorly to concanavalin A (Con A). The response of ES cells was poor to GO and SBA, intermediate to PHA, and significantly high to Con A. The different response of ER and ES subsets to Con A was not greatly affected by adherent cells, but an enhancing effect on the proliferation of ES cells to Con A was observed when prostaglandin synthesis was inhibited by indomethacin. Addition of ES cells to ER cells in a ratio of 1:5 resulted in an enhanced synergistic effect of Con A-induced proliferation. A soluble mitogenic factor released from Con A-activated T cells appeared involved in this enhanced proliferation. This factor (ESF) was produced only by the minor T-cell subpopulation which is sensitive to adenosine (ES). The induction of ESF was not dependent on the addition of adherent cells and required 72 hr of incubation for its production. ESF was mitogenic to nonactivated and Con A-activated PBL as well as to T, ER, and ES subpopulations. Following incubation of ER cells with ESF, a suppressor factor (ERSF) was produced which abolished the mitogenic activity of ESF. Differences between these factors and a known mediator like Interleukin-2 (IL-2) and suppressor factors are discussed." @default.
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- W1552297218 date "1982-11-01" @default.
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- W1552297218 title "The regulatory role of adenosine-activated T-lymphocyte subset on the immune response in humans" @default.
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- W1552297218 doi "https://doi.org/10.1016/0008-8749(82)90451-8" @default.
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