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- W1552311232 abstract "Abstract : We developed an injury model to bone marrow stroma cultured in vitro from bone marrow samples from mice and human donors. We demonstrated that oxidative injury with H2O2 induces a reproducible time- and dose-dependent secretory senescence profile that consists of export of interleukin 6 (IL-6) by murine and human stroma and IL-8 by murine stroma and activation of TGF beta signaling. Using oxidative injury as a positive control, we demonstrated that estrogen deprivation induces secretory senescence in bone marrow stroma both in female mice and a premenopausal human female volunteer and activation of TGF beta signaling in mice. We defined the parameters for estrogen-induced secretory senescence in mouse and human marrow. Preliminary observations suggest that human marrow is more sensitive to estrogen deprivation-induced secretory senescence resulting in a greater and more sustained response. These data will be expanded to define the relationship between post menopausal status and secretory senescence and the effect on this stromal response on the capacity to support micrometastatic breast cancer cell dormancy." @default.
- W1552311232 created "2016-06-24" @default.
- W1552311232 creator A5053615282 @default.
- W1552311232 date "2011-07-01" @default.
- W1552311232 modified "2023-09-24" @default.
- W1552311232 title "Reactivation of Breast Cancer Micrometastases by Senescent Bone Marrow Stroma" @default.
- W1552311232 cites W2111414495 @default.
- W1552311232 doi "https://doi.org/10.21236/ada550871" @default.
- W1552311232 hasPublicationYear "2011" @default.
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