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• W1552324954 abstract "Neurexins (NXs) and neuroligins (NLs) are cell adhesion molecules that are localized at opposite sites of synaptic membranes. They interact with each other to promote the assembly, maintenance, and function of synapses in the central nervous system. Both NX and NL are cleaved from a membrane-attached intracellular domain in an activity-dependent manner, generating the soluble ectodomain of NX or NL. Expression of the NX1 and NX3 genes in the brain appears to be regulated by a schizophrenia-related protein, DISC1. Here, we show that soluble ecto-NX1β can regulate the expression of DISC1 and induce signaling downstream of DISC1. We also show that NL1 binds to a well-characterized DISC1 interaction partner, Kal-7, and this interaction can be compromised by DISC1. Our results indicate that the NX/NL synaptic complex is intrinsically involved in the regulation of DISC1 function, thus contributing to a better understanding of the pathology of schizophrenia." @default.
• W1552324954 created "2016-06-24" @default.
• W1552324954 creator A5010470710 @default.
• W1552324954 creator A5073327202 @default.
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• W1552324954 date "2015-01-01" @default.
• W1552324954 modified "2023-09-22" @default.
• W1552324954 title "Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 “Signalosome”" @default.
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• W1552324954 doi "https://doi.org/10.1155/2015/167308" @default.
• W1552324954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4452847" @default.
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