FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552359306> ?p ?o ?g. }

• W1552359306 abstract "Autophagy is an essential process in the control of cellular homeostasis. It enables cells under certain stress conditions to survive by removing toxic cellular components, and may protect cells from apoptosis. In the present study, the signaling pathways involved in ARV S1133 regulated switch from autophagy to apoptosis were investigated.ARV S1133 infection caused autophagy in the early to middle infectious stages in Vero and DF1 cells, and apoptosis in the middle to late stages. Conversion of the autophagy marker LC3-I to LC3-II occurred earlier than cleavage of the apoptotic marker caspase-3. ARV S1133 also activated the Beclin-1 promoter in the early to middle stages of infection. Levels of RhoA-GTP and ROCK1 activity were elevated upon ARV S1133 infection, while inhibition of RhoA and ROCK1 reduced autophagy and subsequent apoptosis. Conversely, inhibition of caspase-3 did not affect the level of autophagy. Beclin-1 knockdown and treatment with autophagy inhibitors, 3-MA and Bafilomycin A1, suppressed ARV S1133-induced autophagy and apoptosis simultaneously, suggesting the shift from autophagy to apoptosis. A co-immunoprecipitation assay demonstrated that the formation of a RhoA, ROCK1 and Beclin-1 complex coincided with the induction of autophagy.Our results demonstrate that RhoA/ROCK1 signaling play critical roles in the transition of cell activity from autophagy to apoptosis in ARV S1133-infected cells." @default.
• W1552359306 created "2016-06-24" @default.
• W1552359306 creator A5008009646 @default.
• W1552359306 creator A5032845879 @default.
• W1552359306 creator A5036105559 @default.
• W1552359306 creator A5072759274 @default.
• W1552359306 date "2015-05-06" @default.
• W1552359306 modified "2023-09-26" @default.
• W1552359306 title "RhoA/ROCK1 regulates Avian Reovirus S1133-induced switch from autophagy to apoptosis" @default.
• W1552359306 cites W1508695192 @default.
• W1552359306 cites W1526489492 @default.
• W1552359306 cites W1597787921 @default.
• W1552359306 cites W1599366903 @default.
• W1552359306 cites W1964032090 @default.
• W1552359306 cites W1965151763 @default.
• W1552359306 cites W1967869940 @default.
• W1552359306 cites W1974270901 @default.
• W1552359306 cites W1977767269 @default.
• W1552359306 cites W1983831622 @default.
• W1552359306 cites W1985489438 @default.
• W1552359306 cites W1993962581 @default.
• W1552359306 cites W2005877077 @default.
• W1552359306 cites W2015126838 @default.
• W1552359306 cites W2028532536 @default.
• W1552359306 cites W2034132952 @default.
• W1552359306 cites W2038870226 @default.
• W1552359306 cites W2043494467 @default.
• W1552359306 cites W2045842167 @default.
• W1552359306 cites W2046250764 @default.
• W1552359306 cites W2050329108 @default.
• W1552359306 cites W2050487309 @default.
• W1552359306 cites W2050610800 @default.
• W1552359306 cites W2053747768 @default.
• W1552359306 cites W2054733426 @default.
• W1552359306 cites W2055074822 @default.
• W1552359306 cites W2055899031 @default.
• W1552359306 cites W2058919048 @default.
• W1552359306 cites W2063723998 @default.
• W1552359306 cites W2064949318 @default.
• W1552359306 cites W2067497952 @default.
• W1552359306 cites W2074305443 @default.
• W1552359306 cites W2077247026 @default.
• W1552359306 cites W2091681522 @default.
• W1552359306 cites W2102475426 @default.
• W1552359306 cites W2106090383 @default.
• W1552359306 cites W2106476697 @default.
• W1552359306 cites W2115742671 @default.
• W1552359306 cites W2157096314 @default.
• W1552359306 cites W2159155480 @default.
• W1552359306 cites W2166248467 @default.
• W1552359306 cites W2332992421 @default.
• W1552359306 cites W2743254891 @default.
• W1552359306 cites W2410772600 @default.
• W1552359306 doi "https://doi.org/10.1186/s12917-015-0417-6" @default.
• W1552359306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4430033" @default.
• W1552359306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25944062" @default.
• W1552359306 hasPublicationYear "2015" @default.
• W1552359306 type Work @default.
• W1552359306 sameAs 1552359306 @default.
• W1552359306 citedByCount "10" @default.
• W1552359306 countsByYear W15523593062016 @default.
• W1552359306 countsByYear W15523593062017 @default.
• W1552359306 countsByYear W15523593062018 @default.
• W1552359306 countsByYear W15523593062019 @default.
• W1552359306 countsByYear W15523593062020 @default.
• W1552359306 countsByYear W15523593062022 @default.
• W1552359306 countsByYear W15523593062023 @default.
• W1552359306 crossrefType "journal-article" @default.
• W1552359306 hasAuthorship W1552359306A5008009646 @default.
• W1552359306 hasAuthorship W1552359306A5032845879 @default.
• W1552359306 hasAuthorship W1552359306A5036105559 @default.
• W1552359306 hasAuthorship W1552359306A5072759274 @default.
• W1552359306 hasBestOaLocation W15523593061 @default.
• W1552359306 hasConcept C133717845 @default.
• W1552359306 hasConcept C168296220 @default.
• W1552359306 hasConcept C185592680 @default.
• W1552359306 hasConcept C190283241 @default.
• W1552359306 hasConcept C203522944 @default.
• W1552359306 hasConcept C2777093181 @default.
• W1552359306 hasConcept C31573885 @default.
• W1552359306 hasConcept C55493867 @default.
• W1552359306 hasConcept C62478195 @default.
• W1552359306 hasConcept C86803240 @default.
• W1552359306 hasConcept C95444343 @default.
• W1552359306 hasConceptScore W1552359306C133717845 @default.
• W1552359306 hasConceptScore W1552359306C168296220 @default.
• W1552359306 hasConceptScore W1552359306C185592680 @default.
• W1552359306 hasConceptScore W1552359306C190283241 @default.
• W1552359306 hasConceptScore W1552359306C203522944 @default.
• W1552359306 hasConceptScore W1552359306C2777093181 @default.
• W1552359306 hasConceptScore W1552359306C31573885 @default.
• W1552359306 hasConceptScore W1552359306C55493867 @default.
• W1552359306 hasConceptScore W1552359306C62478195 @default.
• W1552359306 hasConceptScore W1552359306C86803240 @default.
• W1552359306 hasConceptScore W1552359306C95444343 @default.
• W1552359306 hasIssue "1" @default.
• W1552359306 hasLocation W15523593061 @default.
• W1552359306 hasLocation W15523593062 @default.
• W1552359306 hasLocation W15523593063 @default.
• W1552359306 hasLocation W15523593064 @default.

• next