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- W1552364238 abstract "Summary The 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase inhibitors (statins) interfere with the mevalonate pathway. While initially developed for their lipid‐lowering properties, statins have been extensively investigated with respect to their impact on autoantigen and alloantigen driven immune responses. Mechanistically it was shown that statins modify immune responses on several levels, including effects on dendritic cells, endothelial cells, macrophages, B cells and T cells. Several lines of evidence suggest that statins act in a disease‐specific manner and are not effective in each immune disorder. This review discusses possible modes of action of statins in modulating immunity towards autoantigens and alloantigens." @default.
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- W1552364238 date "2009-03-31" @default.
- W1552364238 modified "2023-10-16" @default.
- W1552364238 title "Regulation of different inflammatory diseases by impacting the mevalonate pathway" @default.
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- W1552364238 doi "https://doi.org/10.1111/j.1365-2567.2008.03011.x" @default.
- W1552364238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2678178" @default.
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