Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552483141> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1552483141 endingPage "2832" @default.
- W1552483141 startingPage "2825" @default.
- W1552483141 abstract "Abstract We have recently shown that solid-phase immobilization of anti-1F7 recognizing the 110-kDa CD26 Ag is comitogenic for human peripheral blood T cell activation via both the CD3 and CD2 pathways. We have also demonstrated that binding of anti-1F7 leads to the disappearance of CD26 surface expression, and this anti-1F7-induced modulation results in an increase in anti-CD3 or anti-CD2-mediated peripheral blood T cell activation. In this report, we extended these findings by examining the expression and functional relationship of 1F7 on the CD3 and CD2 pathways of activation of human thymocytes. We now demonstrated that most of the anti-1F7 reactivity is found on medullary thymocytes, the population of thymocytes expressing high level of CD3 (CD3H). We have also shown that binding of anti-1F7 can induce a decrease in CD26 surface expression, with no detectable effect on the surface expression of CD3 or CD2. Most importantly, we showed that solid-phase immobilization of anti-1F7 has a comitogenic effect on thymocyte activation induced by anti-CD3 but not anti-CD2. In addition, anti-1F7-induced modulation of CD26 results in an enhancement in CD3-mediated but not CD2-mediated human thymocyte activation. The observed functional effect of CD26 on the CD3/TCR pathway of activation is mainly restricted to mature thymocytes as distinguished by high surface expression of CD5, although CD26 is also functionally associated with the CD3/TCR pathway on cells expressing low level of CD5. Demonstrating that CD26 involvement in the regulation of human thymocyte activation is restricted mainly to the CD3 pathway, unlike its involvement with both the CD3 and CD2 pathways of mature peripheral blood T lymphocyte activation, our data hence suggested that CD26 may play a role in thymic differentiation and maturation via the differential engagement of the CD3 pathway." @default.
- W1552483141 created "2016-06-24" @default.
- W1552483141 creator A5025705701 @default.
- W1552483141 creator A5044287074 @default.
- W1552483141 creator A5045538077 @default.
- W1552483141 creator A5055648823 @default.
- W1552483141 creator A5081535556 @default.
- W1552483141 creator A5082359860 @default.
- W1552483141 creator A5084263169 @default.
- W1552483141 date "1991-11-01" @default.
- W1552483141 modified "2023-10-11" @default.
- W1552483141 title "1F7 (CD26): a marker of thymic maturation involved in the differential regulation of the CD3 and CD2 pathways of human thymocyte activation." @default.
- W1552483141 doi "https://doi.org/10.4049/jimmunol.147.9.2825" @default.
- W1552483141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1717577" @default.
- W1552483141 hasPublicationYear "1991" @default.
- W1552483141 type Work @default.
- W1552483141 sameAs 1552483141 @default.
- W1552483141 citedByCount "57" @default.
- W1552483141 countsByYear W15524831412013 @default.
- W1552483141 countsByYear W15524831412014 @default.
- W1552483141 countsByYear W15524831412015 @default.
- W1552483141 countsByYear W15524831412016 @default.
- W1552483141 countsByYear W15524831412018 @default.
- W1552483141 countsByYear W15524831412021 @default.
- W1552483141 countsByYear W15524831412022 @default.
- W1552483141 countsByYear W15524831412023 @default.
- W1552483141 crossrefType "journal-article" @default.
- W1552483141 hasAuthorship W1552483141A5025705701 @default.
- W1552483141 hasAuthorship W1552483141A5044287074 @default.
- W1552483141 hasAuthorship W1552483141A5045538077 @default.
- W1552483141 hasAuthorship W1552483141A5055648823 @default.
- W1552483141 hasAuthorship W1552483141A5081535556 @default.
- W1552483141 hasAuthorship W1552483141A5082359860 @default.
- W1552483141 hasAuthorship W1552483141A5084263169 @default.
- W1552483141 hasBestOaLocation W15524831411 @default.
- W1552483141 hasConcept C114684123 @default.
- W1552483141 hasConcept C153911025 @default.
- W1552483141 hasConcept C167672396 @default.
- W1552483141 hasConcept C19317047 @default.
- W1552483141 hasConcept C203014093 @default.
- W1552483141 hasConcept C2776090121 @default.
- W1552483141 hasConcept C2778954852 @default.
- W1552483141 hasConcept C86803240 @default.
- W1552483141 hasConcept C8891405 @default.
- W1552483141 hasConcept C95444343 @default.
- W1552483141 hasConceptScore W1552483141C114684123 @default.
- W1552483141 hasConceptScore W1552483141C153911025 @default.
- W1552483141 hasConceptScore W1552483141C167672396 @default.
- W1552483141 hasConceptScore W1552483141C19317047 @default.
- W1552483141 hasConceptScore W1552483141C203014093 @default.
- W1552483141 hasConceptScore W1552483141C2776090121 @default.
- W1552483141 hasConceptScore W1552483141C2778954852 @default.
- W1552483141 hasConceptScore W1552483141C86803240 @default.
- W1552483141 hasConceptScore W1552483141C8891405 @default.
- W1552483141 hasConceptScore W1552483141C95444343 @default.
- W1552483141 hasIssue "9" @default.
- W1552483141 hasLocation W15524831411 @default.
- W1552483141 hasLocation W15524831412 @default.
- W1552483141 hasOpenAccess W1552483141 @default.
- W1552483141 hasPrimaryLocation W15524831411 @default.
- W1552483141 hasRelatedWork W2014863755 @default.
- W1552483141 hasRelatedWork W2016112814 @default.
- W1552483141 hasRelatedWork W2023251818 @default.
- W1552483141 hasRelatedWork W2053350302 @default.
- W1552483141 hasRelatedWork W2072838847 @default.
- W1552483141 hasRelatedWork W2093020311 @default.
- W1552483141 hasRelatedWork W2130147879 @default.
- W1552483141 hasRelatedWork W2150590994 @default.
- W1552483141 hasRelatedWork W2172228770 @default.
- W1552483141 hasRelatedWork W72712021 @default.
- W1552483141 hasVolume "147" @default.
- W1552483141 isParatext "false" @default.
- W1552483141 isRetracted "false" @default.
- W1552483141 magId "1552483141" @default.
- W1552483141 workType "article" @default.