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- W1552497508 abstract "The methyl group is one of the most widespread functionalities and decorates more than 67% of the top-selling drugs of 2011. Although significant advances in synthetic chemistry have been achieved allowing the direct methylation, the need for environmentally benign alternatives is growing. As methylation is one of the most common chemical modifications in living cells, a variety of enzymes catalyzing the introduction of methyl groups has been evolved by nature. The enzymes are called methyltransferases (MTs) and are cofactor-dependent. S-adenosyl-L-methionine (SAM) is by far the most predominant natural source of methyl groups. Since MTs are involved in many cellular processes, their acceptor substrates are diverse, ranging from large biopolymers to small molecules. Their broad substrate spectrum would allow the use of MTs as catalysts for a wide range of biocatalytic methylation and as shown recently for also other alkylation reactions. The technological exploitation is under intensive investigation. As long as an effective recycling system for SAM is lacking, predominantly in vivo applications (cascade reactions using synthetic biology approaches) will emerge." @default.
- W1552497508 created "2016-06-24" @default.
- W1552497508 creator A5000130128 @default.
- W1552497508 creator A5017208101 @default.
- W1552497508 creator A5017614978 @default.
- W1552497508 creator A5047140133 @default.
- W1552497508 date "2014-06-27" @default.
- W1552497508 modified "2023-10-05" @default.
- W1552497508 title "Methyltransferases in Biocatalysis" @default.
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