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• W1552576564 abstract "Objective: to study associations between the lesion of the heart and aorta and other clinical manifestations and the characteristics of ankylosingspondylitis (AS).Subjects and methods. Three hundred and forty-four patients under 60 years of age with a valid diagnosis of AS without concomitant heartdisease, followed up at the Research Institute of Rheumatology, Russian Academy of Medical Sciences, in 2005-2008, were examined. Ofthem, 64 (18.6%) patients had at least one attack of uveitis during the disease; 280 had never uveitis. During the disease, peripheralarthritis occurred in 160 (46.5%) patients; 184 (53.5%) had axial AS. All the patients underwent ECG; 101 had EchoCG (27 with uveitisand 74 without uveitis, 63 with arthritis and 38 without arthritis).Results. Forty-four patients were found to have cardiac conduction disturbances (atrioventricular or left bundle-branch block); ofthem 14 (31.8%) and 30 (68%) had uveitis and peripheral arthritis, respectively. Out of the 300 individuals without conduction disturbances,50 (16.7%) and 130 (43%) had the above conditions (p = 0.01 and 0.003, respectively). Cardiac structural changes(aortic thickening/dilatation, subaortic bump, aortic and/or mitral leaflet thickening) were revealed in 45 patients; among them 21(46.7%) and 34 (75%) had uveitis and arthritis, respectively; of the 56 patients without EchoCG changes, 6 (10.7%) and 29 (51%)had the above conditions (p = 0.0001 and 0.02, respectively). On the other hand, conduction disturbances were noted in 15 (23.4%)of the 64 patients with uveitis and in 29 (10.3%) of the 280 patients without this condition; p = 0.006; in 30 (19%) of the 160patients with peripheral arthritis and in 14 (7.6%) of the 180 patients without arthritis; p = 0.003. Aortic and valvular changes weredetected in 16 (59.2%) of the 27 patients with uveitis and in 28 (37.8%) of 74 without this condition; p = 0.04; in 36 (57%) patientswith arthritis and in 9 (23%) of the 38 without arthritis; p = 0.018. There were no significant differences in the parameters ofinflammatory activity between the groups.Conclusion. In patients with AS, cardiac lesion was significantly more frequently in the presence of uveitis and peripheral arthritis; uveitisand peripheral arthritis were significantly more common in patients with AS-induced cardiac changes." @default.
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• W1552576564 date "2010-10-15" @default.
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• W1552576564 title "ASSOCIATION BETWEEN CARDIAC LESION AND OTHER CLINICAL MANIFESTATIONSOF ANKYLOSING SPONDYLITIS" @default.
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• W1552576564 doi "https://doi.org/10.14412/1995-4484-2010-728" @default.
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