Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552592516> ?p ?o ?g. }
- W1552592516 endingPage "218" @default.
- W1552592516 startingPage "203" @default.
- W1552592516 abstract "Background information The in vitro co‐culture models of communication between normal fibroblasts and epithelial cells, such as keratinocytes or squamous cell carcinoma cells of FaDu line representing wound healing or cancer development, were established by non‐direct contact between the cells and utilised in this study to examine epithelia‐induced changes in overall fibroblast proteome patterns. Results We were able to select the proteins co‐regulated in both models in order to evaluate possible molecular commonalities between wound healing and tumour development. Amongst the most pronounced were the proteins implemented in contractile activity and formation of actin cytoskeleton such as caldesmon, calponin‐2, myosin regulatory light‐chain 12A and cofilin‐1, which were expressed independently of the presence of α‐smooth muscle actin. Additionally, proteins altered differently highlighted functional and cellular phenotypes during transition of fibroblasts towards myofibroblasts or cancer‐associated fibroblasts. Results showed coordinated regulation of cytoskeleton proteins selective for wound healing which were lost in tumourigenesis model. Vimentin bridged this group of proteins with other regulated proteins in human fibroblasts involved in protein or RNA processing and metabolic regulation. Conclusions The findings provide strong support for crucial role of stromal microenvironment in wound healing and tumourigenesis. In particular, epithelia‐induced protein changes in fibroblasts offer new potential targets which may lead to novel tailored cancer therapeutic strategies." @default.
- W1552592516 created "2016-06-24" @default.
- W1552592516 creator A5012449810 @default.
- W1552592516 creator A5012499022 @default.
- W1552592516 creator A5014562746 @default.
- W1552592516 creator A5015988586 @default.
- W1552592516 creator A5037250841 @default.
- W1552592516 creator A5052600113 @default.
- W1552592516 creator A5066224930 @default.
- W1552592516 creator A5078497380 @default.
- W1552592516 creator A5089406477 @default.
- W1552592516 date "2014-05-26" @default.
- W1552592516 modified "2023-10-16" @default.
- W1552592516 title "Revelation of fibroblast protein commonalities and differences and their possible roles in wound healing and tumourigenesis using co-culture models of cells" @default.
- W1552592516 cites W1669342046 @default.
- W1552592516 cites W1683381145 @default.
- W1552592516 cites W1976406494 @default.
- W1552592516 cites W1976809280 @default.
- W1552592516 cites W1981918798 @default.
- W1552592516 cites W1986583100 @default.
- W1552592516 cites W1988850323 @default.
- W1552592516 cites W1991370238 @default.
- W1552592516 cites W1992339843 @default.
- W1552592516 cites W1995342232 @default.
- W1552592516 cites W1996705412 @default.
- W1552592516 cites W2000544718 @default.
- W1552592516 cites W2020068231 @default.
- W1552592516 cites W2027905321 @default.
- W1552592516 cites W2030861211 @default.
- W1552592516 cites W2034400467 @default.
- W1552592516 cites W2049198267 @default.
- W1552592516 cites W2056570671 @default.
- W1552592516 cites W2057630012 @default.
- W1552592516 cites W2058162816 @default.
- W1552592516 cites W2062396873 @default.
- W1552592516 cites W2066313876 @default.
- W1552592516 cites W2074325678 @default.
- W1552592516 cites W2078819422 @default.
- W1552592516 cites W2108413432 @default.
- W1552592516 cites W2125586870 @default.
- W1552592516 cites W2136118033 @default.
- W1552592516 cites W2138516171 @default.
- W1552592516 cites W2144014661 @default.
- W1552592516 cites W2145968706 @default.
- W1552592516 cites W2152235308 @default.
- W1552592516 cites W2152374554 @default.
- W1552592516 cites W2156865492 @default.
- W1552592516 cites W2169045601 @default.
- W1552592516 cites W2314203153 @default.
- W1552592516 doi "https://doi.org/10.1111/boc.201400014" @default.
- W1552592516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24698078" @default.
- W1552592516 hasPublicationYear "2014" @default.
- W1552592516 type Work @default.
- W1552592516 sameAs 1552592516 @default.
- W1552592516 citedByCount "12" @default.
- W1552592516 countsByYear W15525925162015 @default.
- W1552592516 countsByYear W15525925162016 @default.
- W1552592516 countsByYear W15525925162018 @default.
- W1552592516 countsByYear W15525925162019 @default.
- W1552592516 countsByYear W15525925162020 @default.
- W1552592516 countsByYear W15525925162022 @default.
- W1552592516 countsByYear W15525925162023 @default.
- W1552592516 crossrefType "journal-article" @default.
- W1552592516 hasAuthorship W1552592516A5012449810 @default.
- W1552592516 hasAuthorship W1552592516A5012499022 @default.
- W1552592516 hasAuthorship W1552592516A5014562746 @default.
- W1552592516 hasAuthorship W1552592516A5015988586 @default.
- W1552592516 hasAuthorship W1552592516A5037250841 @default.
- W1552592516 hasAuthorship W1552592516A5052600113 @default.
- W1552592516 hasAuthorship W1552592516A5066224930 @default.
- W1552592516 hasAuthorship W1552592516A5078497380 @default.
- W1552592516 hasAuthorship W1552592516A5089406477 @default.
- W1552592516 hasConcept C121608353 @default.
- W1552592516 hasConcept C125705527 @default.
- W1552592516 hasConcept C137738243 @default.
- W1552592516 hasConcept C142669718 @default.
- W1552592516 hasConcept C142724271 @default.
- W1552592516 hasConcept C147447768 @default.
- W1552592516 hasConcept C1491633281 @default.
- W1552592516 hasConcept C16930146 @default.
- W1552592516 hasConcept C203014093 @default.
- W1552592516 hasConcept C204232928 @default.
- W1552592516 hasConcept C207865475 @default.
- W1552592516 hasConcept C2776601116 @default.
- W1552592516 hasConcept C2780269544 @default.
- W1552592516 hasConcept C2780381497 @default.
- W1552592516 hasConcept C2780559512 @default.
- W1552592516 hasConcept C2781122658 @default.
- W1552592516 hasConcept C2993400109 @default.
- W1552592516 hasConcept C502942594 @default.
- W1552592516 hasConcept C54355233 @default.
- W1552592516 hasConcept C55493867 @default.
- W1552592516 hasConcept C71924100 @default.
- W1552592516 hasConcept C81885089 @default.
- W1552592516 hasConcept C86803240 @default.
- W1552592516 hasConcept C95444343 @default.
- W1552592516 hasConcept C96232424 @default.
- W1552592516 hasConceptScore W1552592516C121608353 @default.