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• W1552609875 abstract "By conferring allele‐specific transcriptional activity on the monoamine oxidase A ( MAOA ) gene in humans, length variation of a repetitive sequence [(variable number of tandem repeat (VNTR)] in the MAOA promoter influences a constellation of personality traits related to aggressive and antisocial behavior and increases the risk of neurodevelopmental and psychiatric disorders. Here, we have analyzed the presence and variability of this MAOA promoter repeat in several species of nonhuman primates. Sequence analysis of MAOA 's transcriptional control region revealed the presence of the VNTR in chimpanzee ( Pan troglodytes ), bonobo ( Pan paniscus ), gorilla ( Gorilla gorilla ), orangutan ( Pongo pygmaeus ), rhesus macaque ( Macaca mulatta ) and Gelada baboon ( Theropithecus gelada ). The majority of P. troglodytes and P. paniscus showed a single repeat with a sequence identical to the VNTR sequence in humans. In contrast, analyses of the remaining species revealed shorter sequences similar to the first 18 bp of human VNTR. Compared with other nonhuman primates, the VNTR sequence of M. mulatta showed the highest length variability with allele frequencies of 35, 25 and 40% for the five, six and seven repeat variants, respectively. The extent of variability of the MAOA promoter repeat in both rhesus monkeys and humans supports the notion that there may be a relationship between functional MAOA expression and aggression‐related traits in humans and rhesus macaque populations." @default.
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• W1552609875 date "2005-07-25" @default.
• W1552609875 modified "2023-10-18" @default.
• W1552609875 title "Structural variation of the <i>monoamine oxidase A</i> gene promoter repeat polymorphism in nonhuman primates" @default.
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• W1552609875 doi "https://doi.org/10.1111/j.1601-183x.2005.00130.x" @default.
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