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- W1552625976 abstract "Current consensus guidelines recommend the use of proton pump inhibitors (PPIs) for the prevention of gastrointestinal bleeding in patients receiving dual antiplatelet therapy (DAPT) with clopidogrel and aspirin. Metabolism of both PPIs and clopidogrel involves the cytochrome-P450 (CYP450) system. Concomitant use of these drugs may result in the competitive inhibition of CYP2C19 and reduced clopidogrel action. The evidence available to date for a drug interaction is conflicting and relies heavily on observational data. Until further evidence become available, it is recommended that health care professionals avoid the concomitant use of clopidogrel and PPIs unless absolutely necessary and only when there is a clear indication such as for peptic ulcer disease or H. pylori eradication. Pantoprazole may be the preferred PPI although current evidence are inconclusive. H2 antagonists may be a suitable alternative to PPIs." @default.
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- W1552625976 date "2012-12-31" @default.
- W1552625976 modified "2023-09-27" @default.
- W1552625976 title "Proton Pump Inhibitors and Clopidogrel: A Review of the Interaction" @default.
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