Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552641940> ?p ?o ?g. }
- W1552641940 endingPage "47" @default.
- W1552641940 startingPage "36" @default.
- W1552641940 abstract "A major lipid-signaling pathway in mammalian cells implicates the generation of ceramide from the ubiquitous sphingolipid sphingomyelin (SM). Hydrolysis of SM by a sphingomyelinase present in acidic compartments has been reported to mediate, via the production of ceramide, the apoptotic cell death triggered by stress-inducing agents. In the present study, we investigated whether the ceramide formed within or accumulated in lysosomes indeed triggers apoptosis. A series of observations strongly suggests that ceramide involved in stress-induced apoptosis is not endolysosomal: 1) Although short-chain ceramides induced apoptosis, loading cells with natural ceramide through receptor-mediated endocytosis did not result in cell death. 2) Neither TNF-alpha nor anti-CD95 induced the degradation to ceramide of a natural SM that had been first introduced selectively into acidic compartments. 3) Stimulation of SV40-transformed fibroblasts by TNF-alpha or CD40 ligand resulted in apoptosis equally well in cells derived from control individuals and from patients affected with Farber disease, having a genetic defect of acid ceramidase activity leading to lysosomal accumulation of ceramide. Also, induction of apoptosis using anti-CD95 (Fas) or anti-CD40 antibodies, TNF-alpha, daunorubicin, and ionizing radiation was similar in control and Farber disease lymphoid cells. In all cases, apoptosis was preceded by a comparable increase of intracellular ceramide levels. 4) Retroviral-mediated gene transfer and overexpression of acid ceramidase in Farber fibroblasts, which led to complete metabolic correction of the ceramide catabolic defect, did not affect the cell response to TNF-alpha and CD40 ligand." @default.
- W1552641940 created "2016-06-24" @default.
- W1552641940 creator A5008268675 @default.
- W1552641940 creator A5017809308 @default.
- W1552641940 creator A5033158463 @default.
- W1552641940 creator A5038403474 @default.
- W1552641940 creator A5040785436 @default.
- W1552641940 creator A5050882941 @default.
- W1552641940 creator A5068677784 @default.
- W1552641940 creator A5073545182 @default.
- W1552641940 creator A5075378844 @default.
- W1552641940 creator A5075593404 @default.
- W1552641940 creator A5080673541 @default.
- W1552641940 date "2000-01-01" @default.
- W1552641940 modified "2023-10-13" @default.
- W1552641940 title "Stress‐induced apoptosis is not mediated by endolysosomal ceramide" @default.
- W1552641940 cites W1446970532 @default.
- W1552641940 cites W1484441747 @default.
- W1552641940 cites W1490342290 @default.
- W1552641940 cites W1530553925 @default.
- W1552641940 cites W1557290711 @default.
- W1552641940 cites W1570625443 @default.
- W1552641940 cites W1605902541 @default.
- W1552641940 cites W171737858 @default.
- W1552641940 cites W1843461492 @default.
- W1552641940 cites W1896222682 @default.
- W1552641940 cites W1942046185 @default.
- W1552641940 cites W1969158591 @default.
- W1552641940 cites W1970054633 @default.
- W1552641940 cites W1975242912 @default.
- W1552641940 cites W1981412298 @default.
- W1552641940 cites W1982003581 @default.
- W1552641940 cites W1984745753 @default.
- W1552641940 cites W1985912672 @default.
- W1552641940 cites W1990291541 @default.
- W1552641940 cites W1995339668 @default.
- W1552641940 cites W2000823512 @default.
- W1552641940 cites W2003474943 @default.
- W1552641940 cites W2004038270 @default.
- W1552641940 cites W2007604755 @default.
- W1552641940 cites W2011495375 @default.
- W1552641940 cites W2013672165 @default.
- W1552641940 cites W2014664200 @default.
- W1552641940 cites W2017729786 @default.
- W1552641940 cites W2020770410 @default.
- W1552641940 cites W2024149904 @default.
- W1552641940 cites W2028652974 @default.
- W1552641940 cites W2028714428 @default.
- W1552641940 cites W2036009804 @default.
- W1552641940 cites W2039635195 @default.
- W1552641940 cites W2041576624 @default.
- W1552641940 cites W2049108649 @default.
- W1552641940 cites W2053858732 @default.
- W1552641940 cites W2056344898 @default.
- W1552641940 cites W2056641203 @default.
- W1552641940 cites W2057049237 @default.
- W1552641940 cites W2061190777 @default.
- W1552641940 cites W2064874874 @default.
- W1552641940 cites W2069279418 @default.
- W1552641940 cites W2070005836 @default.
- W1552641940 cites W2074337499 @default.
- W1552641940 cites W2075222693 @default.
- W1552641940 cites W2079190492 @default.
- W1552641940 cites W2080142147 @default.
- W1552641940 cites W2091800193 @default.
- W1552641940 cites W2092562916 @default.
- W1552641940 cites W2094336459 @default.
- W1552641940 cites W2096012158 @default.
- W1552641940 cites W2117495711 @default.
- W1552641940 cites W2126544407 @default.
- W1552641940 cites W2128821991 @default.
- W1552641940 cites W2130007939 @default.
- W1552641940 cites W2135687585 @default.
- W1552641940 cites W2135772628 @default.
- W1552641940 cites W2142428209 @default.
- W1552641940 cites W2151707666 @default.
- W1552641940 cites W2164578164 @default.
- W1552641940 cites W2168526937 @default.
- W1552641940 cites W2179786763 @default.
- W1552641940 cites W2316467830 @default.
- W1552641940 cites W2342329062 @default.
- W1552641940 cites W2344590584 @default.
- W1552641940 doi "https://doi.org/10.1096/fasebj.14.1.36" @default.
- W1552641940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10627278" @default.
- W1552641940 hasPublicationYear "2000" @default.
- W1552641940 type Work @default.
- W1552641940 sameAs 1552641940 @default.
- W1552641940 citedByCount "58" @default.
- W1552641940 countsByYear W15526419402012 @default.
- W1552641940 countsByYear W15526419402013 @default.
- W1552641940 countsByYear W15526419402015 @default.
- W1552641940 countsByYear W15526419402016 @default.
- W1552641940 countsByYear W15526419402021 @default.
- W1552641940 countsByYear W15526419402022 @default.
- W1552641940 crossrefType "journal-article" @default.
- W1552641940 hasAuthorship W1552641940A5008268675 @default.
- W1552641940 hasAuthorship W1552641940A5017809308 @default.
- W1552641940 hasAuthorship W1552641940A5033158463 @default.