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- W1552673007 abstract "COPD patients may need supplemental oxygen during air travel to avoid development of severe hypoxemia. The study evaluated if Hypoxia-altitude-simulation-test (HAST) can be used to establish the dose of supplemental oxygen required during air travel. Also, the principles of the different oxygen equipment allowed for air travel, were compared. In a randomised crossover trial, 16 COPD patients were exposed to hypoxia simulating aircraft conditions; in a 8000ft hypobaric chamber (HC), and by breathing 15.1% oxygen (HAST). During both tests, supplemental oxygen was given by nasal cannula (NC) with a) continuous flow, b) oxygen-conserving-device, and c) portable oxygen concentrator (POC). PaO2 (kPa) during HC and HAST with supplemental O2 2 L/min (or pulse setting 2) with devices a-c was: a) 8.6 ± 1.1 vs. 12.5 ± 2.4 (p < 0.001), b) 8.6 ± 1.6 vs. 9.7 ± 1.5 (p < 0.001), and c) 7.7 ± 0.9 vs. 8.2 ± 1.1 (p < 0.003), respectively. Oxygen titration by NC during HAST is not reliable due to accumulation of oxygen within the facemask. Comparison of the different oxygen equipment in the HC showed that compressed gaseous oxygen with continuous flow or oxygen-conserving-device gave the same PaO2, while the tested POC gave significantly lower PaO2 values. However, if increasing the dose, acceptable in-flight PaO2 values may also be achieved by using the POC." @default.
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- W1552673007 date "2011-09-20" @default.
- W1552673007 modified "2023-09-25" @default.
- W1552673007 title "Pre-flight titration of supplemental oxygen in COPD patients planning to travel by air" @default.
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- W1552673007 doi "https://doi.org/10.1111/j.1752-699x.2011.00266_8.x" @default.
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