Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552804873> ?p ?o ?g. }
- W1552804873 endingPage "256" @default.
- W1552804873 startingPage "252" @default.
- W1552804873 abstract "Wounds associated with injuries such as burns can produce moderate to severe pain. Besides causing distress to the patient, unrelieved pain could delay healing owing to stress-related problems. Thus, pain needs to be treated as early as possible after injury. It was hypothesised that local treatment of wounds with appropriate analgesic drugs could attenuate pain. HOE 140, a bradykinin receptor antagonist, reduced acute inflammatory pain in rats after intrawound administration. In this study, the analgesic effect of dimethylsulphoxide (DMSO) was investigated in a similar hind-paw incision model in rats. An extremely small quantity (10 µl) of 100% DMSO was administered into the incision site just before closure of the wound. It persistently attenuated guarding behaviour in rats over a period of 3 days without affecting thermal hyperalgesia or allodynia. Accumulated evidence indicates that guarding is equivalent to pain at rest in humans. The possible mechanisms of the analgesic effect could be inhibition of C group of peripheral nerve fibres or even free radical scavenging. Healing of the wound was found to be normal at the end of the study period. In conclusion, DMSO could be useful in the treatment of acute pain resulting from tissue injuries such as burns." @default.
- W1552804873 created "2016-06-24" @default.
- W1552804873 creator A5012173215 @default.
- W1552804873 creator A5013131093 @default.
- W1552804873 creator A5046040229 @default.
- W1552804873 creator A5053741617 @default.
- W1552804873 creator A5075001671 @default.
- W1552804873 creator A5087859039 @default.
- W1552804873 date "2014-04-21" @default.
- W1552804873 modified "2023-09-24" @default.
- W1552804873 title "Direct intrawound administration of dimethylsulphoxide relieves acute pain in rats" @default.
- W1552804873 cites W1969278940 @default.
- W1552804873 cites W1970008312 @default.
- W1552804873 cites W1974876331 @default.
- W1552804873 cites W1975293054 @default.
- W1552804873 cites W1979815637 @default.
- W1552804873 cites W1981810830 @default.
- W1552804873 cites W1984550263 @default.
- W1552804873 cites W1985421715 @default.
- W1552804873 cites W2011419883 @default.
- W1552804873 cites W2014007136 @default.
- W1552804873 cites W2017003391 @default.
- W1552804873 cites W2017794171 @default.
- W1552804873 cites W2032408487 @default.
- W1552804873 cites W2045498700 @default.
- W1552804873 cites W2057114546 @default.
- W1552804873 cites W2060270975 @default.
- W1552804873 cites W2060658170 @default.
- W1552804873 cites W2068989103 @default.
- W1552804873 cites W2072968157 @default.
- W1552804873 cites W2075715972 @default.
- W1552804873 cites W2077239893 @default.
- W1552804873 cites W2082445626 @default.
- W1552804873 cites W2084289720 @default.
- W1552804873 cites W2102897502 @default.
- W1552804873 cites W2107063571 @default.
- W1552804873 cites W2108004092 @default.
- W1552804873 cites W2125186579 @default.
- W1552804873 cites W2128027922 @default.
- W1552804873 cites W2136594448 @default.
- W1552804873 cites W2140115878 @default.
- W1552804873 cites W2146905193 @default.
- W1552804873 cites W2151225878 @default.
- W1552804873 cites W2152605894 @default.
- W1552804873 cites W2155524482 @default.
- W1552804873 cites W2172201406 @default.
- W1552804873 cites W2315004237 @default.
- W1552804873 cites W4232987820 @default.
- W1552804873 doi "https://doi.org/10.1111/iwj.12280" @default.
- W1552804873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7949562" @default.
- W1552804873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24750992" @default.
- W1552804873 hasPublicationYear "2014" @default.
- W1552804873 type Work @default.
- W1552804873 sameAs 1552804873 @default.
- W1552804873 citedByCount "3" @default.
- W1552804873 countsByYear W15528048732015 @default.
- W1552804873 crossrefType "journal-article" @default.
- W1552804873 hasAuthorship W1552804873A5012173215 @default.
- W1552804873 hasAuthorship W1552804873A5013131093 @default.
- W1552804873 hasAuthorship W1552804873A5046040229 @default.
- W1552804873 hasAuthorship W1552804873A5053741617 @default.
- W1552804873 hasAuthorship W1552804873A5075001671 @default.
- W1552804873 hasAuthorship W1552804873A5087859039 @default.
- W1552804873 hasBestOaLocation W15528048732 @default.
- W1552804873 hasConcept C126322002 @default.
- W1552804873 hasConcept C141071460 @default.
- W1552804873 hasConcept C15490471 @default.
- W1552804873 hasConcept C170493617 @default.
- W1552804873 hasConcept C2777883359 @default.
- W1552804873 hasConcept C2779245659 @default.
- W1552804873 hasConcept C2780820201 @default.
- W1552804873 hasConcept C2993997175 @default.
- W1552804873 hasConcept C42219234 @default.
- W1552804873 hasConcept C71924100 @default.
- W1552804873 hasConceptScore W1552804873C126322002 @default.
- W1552804873 hasConceptScore W1552804873C141071460 @default.
- W1552804873 hasConceptScore W1552804873C15490471 @default.
- W1552804873 hasConceptScore W1552804873C170493617 @default.
- W1552804873 hasConceptScore W1552804873C2777883359 @default.
- W1552804873 hasConceptScore W1552804873C2779245659 @default.
- W1552804873 hasConceptScore W1552804873C2780820201 @default.
- W1552804873 hasConceptScore W1552804873C2993997175 @default.
- W1552804873 hasConceptScore W1552804873C42219234 @default.
- W1552804873 hasConceptScore W1552804873C71924100 @default.
- W1552804873 hasIssue "2" @default.
- W1552804873 hasLocation W15528048731 @default.
- W1552804873 hasLocation W15528048732 @default.
- W1552804873 hasLocation W15528048733 @default.
- W1552804873 hasOpenAccess W1552804873 @default.
- W1552804873 hasPrimaryLocation W15528048731 @default.
- W1552804873 hasRelatedWork W1552804873 @default.
- W1552804873 hasRelatedWork W1965729530 @default.
- W1552804873 hasRelatedWork W1985325310 @default.
- W1552804873 hasRelatedWork W1997546463 @default.
- W1552804873 hasRelatedWork W2025235669 @default.
- W1552804873 hasRelatedWork W2035781896 @default.
- W1552804873 hasRelatedWork W2038851034 @default.
- W1552804873 hasRelatedWork W2099849259 @default.