FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1552807357> ?p ?o ?g. }

• W1552807357 endingPage "9850" @default.
• W1552807357 startingPage "9838" @default.
• W1552807357 abstract "Tissue inhibitors of metalloproteinases 3 (TIMP3) were originally characterized as inhibitors of matrix metalloproteinases (MMPs), acting as potent antiangiogenic proteins. In this study, we demonstrated that the arylsulfonamide derivative MPT0G013 has potent antiangiogenic activities in vitro and in vivo viainducing TIMP3 expression. Treatments with MPT0G013 significantly inhibited endothelial cell functions, such as cell proliferation, migration, and tube formation, as well as induced p21 and cell cycle arrest at the G0/G1 phase. Subsequent microarray analysis showed significant induction of TIMP3 gene expression by MPT0G013, and siRNA-mediated blockage of TIMP3 up-regulation abrogated the antiangiogenic activities of MPT0G013 and prevented inhibition of p-AKT and p-ERK proteins. Importantly, MPT0G013 exhibited antiangiogenic activities in in vivo Matrigel plug assays, inhibited tumor growth and up-regulated TIMP3 and p21 proteins in HCT116 mouse xenograft models. These data suggest potential therapeutic application of MPT0G013 for angiogenesis-related diseases such as cancer." @default.
• W1552807357 created "2016-06-24" @default.
• W1552807357 creator A5009943756 @default.
• W1552807357 creator A5018790712 @default.
• W1552807357 creator A5024295450 @default.
• W1552807357 creator A5024894709 @default.
• W1552807357 creator A5045809258 @default.
• W1552807357 creator A5046195308 @default.
• W1552807357 creator A5063329944 @default.
• W1552807357 creator A5075967549 @default.
• W1552807357 creator A5078482756 @default.
• W1552807357 date "2014-09-08" @default.
• W1552807357 modified "2023-09-26" @default.
• W1552807357 title "A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression" @default.
• W1552807357 cites W1207426566 @default.
• W1552807357 cites W1549954866 @default.
• W1552807357 cites W1966906920 @default.
• W1552807357 cites W1967600348 @default.
• W1552807357 cites W1990509128 @default.
• W1552807357 cites W1991394829 @default.
• W1552807357 cites W1995383665 @default.
• W1552807357 cites W2002771508 @default.
• W1552807357 cites W2008745393 @default.
• W1552807357 cites W2015125784 @default.
• W1552807357 cites W2016799783 @default.
• W1552807357 cites W2016977736 @default.
• W1552807357 cites W2033133353 @default.
• W1552807357 cites W2038197915 @default.
• W1552807357 cites W2059148084 @default.
• W1552807357 cites W2063213038 @default.
• W1552807357 cites W2063226520 @default.
• W1552807357 cites W2076278473 @default.
• W1552807357 cites W2084740377 @default.
• W1552807357 cites W2117270333 @default.
• W1552807357 cites W2132100674 @default.
• W1552807357 cites W2132152267 @default.
• W1552807357 cites W2140088548 @default.
• W1552807357 cites W2147240914 @default.
• W1552807357 cites W2148383035 @default.
• W1552807357 cites W2166859762 @default.
• W1552807357 cites W2167714337 @default.
• W1552807357 cites W2793323124 @default.
• W1552807357 cites W4237589349 @default.
• W1552807357 cites W4250428608 @default.
• W1552807357 cites W4252513698 @default.
• W1552807357 doi "https://doi.org/10.18632/oncotarget.2451" @default.
• W1552807357 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4259441" @default.
• W1552807357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25226613" @default.
• W1552807357 hasPublicationYear "2014" @default.
• W1552807357 type Work @default.
• W1552807357 sameAs 1552807357 @default.
• W1552807357 citedByCount "10" @default.
• W1552807357 countsByYear W15528073572015 @default.
• W1552807357 countsByYear W15528073572016 @default.
• W1552807357 countsByYear W15528073572018 @default.
• W1552807357 countsByYear W15528073572019 @default.
• W1552807357 countsByYear W15528073572020 @default.
• W1552807357 countsByYear W15528073572021 @default.
• W1552807357 crossrefType "journal-article" @default.
• W1552807357 hasAuthorship W1552807357A5009943756 @default.
• W1552807357 hasAuthorship W1552807357A5018790712 @default.
• W1552807357 hasAuthorship W1552807357A5024295450 @default.
• W1552807357 hasAuthorship W1552807357A5024894709 @default.
• W1552807357 hasAuthorship W1552807357A5045809258 @default.
• W1552807357 hasAuthorship W1552807357A5046195308 @default.
• W1552807357 hasAuthorship W1552807357A5063329944 @default.
• W1552807357 hasAuthorship W1552807357A5075967549 @default.
• W1552807357 hasAuthorship W1552807357A5078482756 @default.
• W1552807357 hasBestOaLocation W15528073571 @default.
• W1552807357 hasConcept C104317684 @default.
• W1552807357 hasConcept C109523444 @default.
• W1552807357 hasConcept C150194340 @default.
• W1552807357 hasConcept C150903083 @default.
• W1552807357 hasConcept C185592680 @default.
• W1552807357 hasConcept C207001950 @default.
• W1552807357 hasConcept C2775958869 @default.
• W1552807357 hasConcept C2775965246 @default.
• W1552807357 hasConcept C2778271429 @default.
• W1552807357 hasConcept C2778608917 @default.
• W1552807357 hasConcept C2780394083 @default.
• W1552807357 hasConcept C502942594 @default.
• W1552807357 hasConcept C55493867 @default.
• W1552807357 hasConcept C57074206 @default.
• W1552807357 hasConcept C62112901 @default.
• W1552807357 hasConcept C62478195 @default.
• W1552807357 hasConcept C8415881 @default.
• W1552807357 hasConcept C86803240 @default.
• W1552807357 hasConcept C95444343 @default.
• W1552807357 hasConceptScore W1552807357C104317684 @default.
• W1552807357 hasConceptScore W1552807357C109523444 @default.
• W1552807357 hasConceptScore W1552807357C150194340 @default.
• W1552807357 hasConceptScore W1552807357C150903083 @default.
• W1552807357 hasConceptScore W1552807357C185592680 @default.
• W1552807357 hasConceptScore W1552807357C207001950 @default.
• W1552807357 hasConceptScore W1552807357C2775958869 @default.
• W1552807357 hasConceptScore W1552807357C2775965246 @default.
• W1552807357 hasConceptScore W1552807357C2778271429 @default.
• W1552807357 hasConceptScore W1552807357C2778608917 @default.

• next