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- W1552828035 abstract "Phospholipase C (PLC) ε is directly regulated by Ras and Rap1 small GTPases: Ras and Rap1, in their GTP‐bound form, interact with the Ras/Rap1‐associationg (RA) domain of PLCε, thereby translocating PLCε to the plasma membrane and the Golgi apparatus, respectively. In the plasma membrane and the Golgi apparatus, PLCε acts as a phosphoinositide‐specific PLC, regulating various downstream signaling pathways. PLCε also contains a CDC25 homology domain, which enhances guanine nucleotide exchange on Rap1. Here, we describe biochemical characterization of the CDC25 homology domain of PLCε and provide insights into its physiological role in the regulation of PLCε activity." @default.
- W1552828035 created "2016-06-24" @default.
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- W1552828035 date "2006-01-01" @default.
- W1552828035 modified "2023-09-25" @default.
- W1552828035 title "Phospholipase Cε Guanine Nucleotide Exchange Factor Activity and Activation of Rap1" @default.
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- W1552828035 doi "https://doi.org/10.1016/s0076-6879(05)07024-2" @default.
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