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- W1552873435 endingPage "328" @default.
- W1552873435 startingPage "311" @default.
- W1552873435 abstract "Myocardial infarction is the leading cause of heart failure. Current therapy for acute myocardial infarction is to reopen the occluded coronary artery and reperfuse the effected myocardium in an effort to salvage the heart muscle at risk. Through understanding the process of free radical generation in the ischemic and postischemic heart, salvage of heart muscle at risk can be achieved with prevention of secondary heart failure. This chapter talks about the beneficial and deleterious effects of oxygen in the heart. Next, it discusses the sources of reactive oxygen species (ROS) during cardiac ischemia and reperfusion. ROS are known to cause cell death via oxidative stress. It explains the modulation of substrates, metabolites, and cofactors during I-R. The chapter provides discussions on ROS-mediated cellular communication during I-R, and ROS and cell death during ischemic and reperfusion. It finally explains the cardioprotective strategies against ischemia and reperfusion." @default.
- W1552873435 created "2016-06-24" @default.
- W1552873435 creator A5007881879 @default.
- W1552873435 creator A5053625408 @default.
- W1552873435 date "2013-06-28" @default.
- W1552873435 modified "2023-09-23" @default.
- W1552873435 title "Cardiac Ischemia and Reperfusion" @default.
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